Ono K, Yamanaga Y, Yamamoto K, Koga S I, Nishimura J, Nawata H
Third Department of Internal Medicine, Kyushu University, Fukuoka, Japan.
J Clin Immunol. 1996 Jan;16(1):41-5. doi: 10.1007/BF01540971.
Previously we proposed a new analysis of natural killing activity, for comparison, employing an individual effector/target cell ratio according to the peripheral number of effector cells. Using this analysis, we studied natural killing activities in chronic liver diseases and hepatocellular carcinoma (HCC). The activity in chronic persistent hepatitis remained nearly at the level of the nonactivated state, but that was significantly elevated in chronic active hepatitis. The activity in liver cirrhosis (LC) of Child's A or B grade was at the level of a nonactivated or reduced-activity state, while LC patients with impaired general conditions showed significantly elevated activities. In HCC, each of which was accompanied by LC in our cases, the activity appeared to be associated with the progression of HCC. Thus, natural killing activity showed a close relationship with the condition of chronic liver diseases.
此前，我们提出了一种新的自然杀伤活性分析方法，为作比较，该方法根据效应细胞的外周数量采用个体效应细胞/靶细胞比率。利用这种分析方法，我们研究了慢性肝病和肝细胞癌（HCC）中的自然杀伤活性。慢性持续性肝炎中的活性几乎保持在未激活状态的水平，但在慢性活动性肝炎中则显著升高。Child's A级或B级肝硬化（LC）中的活性处于未激活或活性降低状态的水平，而全身状况受损的LC患者的活性则显著升高。在我们的病例中，每个HCC病例都伴有LC，其活性似乎与HCC的进展相关。因此，自然杀伤活性与慢性肝病的病情密切相关。
