易位：一种绕过 CRISPR 的方法。

Transposition: A CRISPR Way to Get Around.

机构信息

Environment and Sustainability Institute, Biosciences, University of Exeter, Cornwall Campus, Penryn, Cornwall TR10 9FE, UK.

Department of Mathematical Sciences, University of Bath, Claverton Down, Bath, Somerset BA2 7AY, UK.

出版信息

Curr Biol. 2019 Sep 23;29(18):R886-R889. doi: 10.1016/j.cub.2019.08.010.

DOI:10.1016/j.cub.2019.08.010

PMID:31550477

Abstract

CRISPR-Cas systems provide sequence-specific immunity against selfish genetic elements in prokaryotes. Now, two studies show that transposon-encoded variants can guide sequence-specific transposition. These findings have important practical implications but also raise questions of why and how this strategy would benefit transposons.

摘要

CRISPR-Cas 系统为原核生物提供了针对自私遗传元件的序列特异性免疫。现在，两项研究表明转座子编码的变体可以指导序列特异性转座。这些发现具有重要的实际意义，但也提出了为什么以及这种策略如何使转座子受益的问题。