Maleki Nasim, Androulakis Xiao Michelle
Psychiatric Neuroimaging Division, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Columbia VA Health Care System, Columbia, SC, United States.
Front Neurol. 2019 Sep 6;10:961. doi: 10.3389/fneur.2019.00961. eCollection 2019.
There has been accumulating evidence on sex disparity in incidence, prevalence, symptomology, and burden of migraine. Several neuroimaging studies on migraine patients attempted to unravel the mechanisms of the disease, yet very few of them examined the sex-related differences. Here, we will first discuss some of the reported neuroimaging patterns that discriminate females from males in migraine. We will then re-examine the salient neuroimaging findings in migraine and discuss them in relation to sex-related influences. Finally, we will discuss some of the intriguing recent data suggesting the presence of sex-specific traits in migraineurs. These findings may have potential implications for future neuroimaging studies to identify underlying correlating patterns in the brain to (1) explain the neural basis for higher prevalence of migraine in women, and (2) better understand migraine-specific changes during different stages of life in both men and women.
关于偏头痛的发病率、患病率、症状及负担方面的性别差异，已有越来越多的证据。多项针对偏头痛患者的神经影像学研究试图揭示该疾病的发病机制，但其中很少有研究考察性别相关差异。在此，我们将首先讨论一些已报道的在偏头痛中区分女性和男性的神经影像学模式。然后，我们将重新审视偏头痛中显著的神经影像学发现，并结合性别相关影响进行讨论。最后，我们将讨论一些近期有趣的数据，这些数据表明偏头痛患者存在性别特异性特征。这些发现可能对未来的神经影像学研究具有潜在意义，以确定大脑中的潜在相关模式，从而（1）解释女性偏头痛患病率较高的神经基础，以及（2）更好地理解男性和女性在生命不同阶段偏头痛的特异性变化。
