Cá Baltazar, Fonseca Kaori L, Sousa Jeremy, Maceiras Ana Raquel, Machado Diana, Sanca Lilica, Rabna Paulo, Rodrigues Pedro N S, Viveiros Miguel, Saraiva Margarida
i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Front Microbiol. 2019 Sep 10;10:2102. doi: 10.3389/fmicb.2019.02102. eCollection 2019.
Tuberculosis remains a public health problem and a main cause of death to humans. Both and cause tuberculosis. In contrast to , which is geographically spread, is restricted to West Africa. Differences have also been found in the growth rate and type of disease caused by , globally suggesting an attenuation of this bacteria. In this study, we used the mouse model of infection to follow the dynamics of infection in terms of bacterial burdens and tissue pathology, as well as the immune response triggered. Our findings support a lower virulence of as compared to , including in mice lacking IFN-γ, a major protective cytokine in tuberculosis. Furthermore, the lung immune response triggered by infection in wild-type animals was characterized by a discrete influx of leukocytes and a modest transcriptional upregulation of inflammatory mediators. Our findings contribute to elucidate the pathogenesis of , supporting the hypothesis that this is an attenuated member of the tuberculosis-causing bacteria. Understanding the biology of and how it interacts with the host to establish infection will have implications for our knowledge of TB and for the development of novel and better tools to control this devastating disease.
结核病仍然是一个公共卫生问题，也是人类死亡的主要原因。[两种细菌名称]都可导致结核病。与在地理上广泛传播的[一种细菌名称]不同，[另一种细菌名称]仅限于西非。在[另一种细菌名称]的全球生长速率和所引发疾病类型方面也发现了差异，这表明该细菌出现了衰减。在本研究中，我们使用感染小鼠模型来追踪[另一种细菌名称]感染在细菌载量、组织病理学以及所引发免疫反应方面的动态变化。我们的研究结果支持[另一种细菌名称]相比于[一种细菌名称]毒力较低，包括在缺乏干扰素-γ（结核病中的一种主要保护性细胞因子）的小鼠中也是如此。此外，野生型动物中由[另一种细菌名称]感染引发的肺部免疫反应的特征是白细胞的离散性流入以及炎症介质的适度转录上调。我们的研究结果有助于阐明[另一种细菌名称]的发病机制，支持了该细菌是导致结核病的细菌中一种衰减成员的假说。了解[另一种细菌名称]的生物学特性以及它如何与宿主相互作用以建立感染，将对我们对结核病的认识以及开发控制这种毁灭性疾病的新型更好工具具有重要意义。
