Orem Jackson
Uganda Cancer Institute, Upper Mulago Hill Road, PO Box 3935, Kampala, Uganda.
Ecancermedicalscience. 2019 Jul 25;13:951. doi: 10.3332/ecancer.2019.951. eCollection 2019.
Kaposi's sarcoma (KS) is a vascular tumour of endothelial origin that is associated with human herpes virus-8 infection. In sub-Saharan Africa, AIDS-KS remains the most common HIV-associated malignancy, and hence it poses a huge burden to the already constrained health-care systems. KS has four clinical variants, namely, classic, endemic, iatrogenic and epidemic KS. The histopathology in these different KS forms is essentially identical; however, they have different clinical patterns. Expanding knowledge of KS biology increases hope for prevention, disease control, and hence better quality of life among patients. Primary prevention strategy for KS-associated herpes virus and management of disease complication, such as lymphoedema should be the focus of disease-prevention and -control research.
卡波西肉瘤（KS）是一种起源于内皮细胞的血管肿瘤，与人类疱疹病毒8型感染有关。在撒哈拉以南非洲，艾滋病相关卡波西肉瘤仍然是最常见的与艾滋病毒相关的恶性肿瘤，因此给本已捉襟见肘的医疗保健系统带来了巨大负担。卡波西肉瘤有四种临床变体，即经典型、地方性、医源性和流行性卡波西肉瘤。这些不同形式的卡波西肉瘤的组织病理学基本相同；然而，它们有不同的临床模式。对卡波西肉瘤生物学认识的不断扩展，增加了预防、疾病控制以及从而改善患者生活质量的希望。与卡波西肉瘤相关疱疹病毒的一级预防策略以及疾病并发症（如淋巴水肿）的管理，应成为疾病预防和控制研究的重点。
