Dwivedi Kartikey Dhar, Borah Biplob, Chowhan L Raju
Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar, India.
Front Chem. 2020 Jan 22;7:944. doi: 10.3389/fchem.2019.00944. eCollection 2019.
Here, we have developed a novel, simple, efficient, and green protocol for one-pot synthesis of pyrano[2,3]pyrazole using arylidene malononitrile and pyrazolone in Water Extract of Banana Peels (WEB) as a reaction medium at room temperature (r.t.). This is a green and general synthetic protocol without utilization of any toxic organic solvent, ligand, base that could be applicable for the wide substrate scope in good to excellent yields. This protocol has various advantages such as fast reactions, eco-friendly reaction conditions, easy isolation of the product without using column chromatography. The green chemistry matrices calculation like atom economy reaction, environmental factor, as well as process mass intensity indicates the eco-friendly nature of the protocol.
在此，我们开发了一种新颖、简单、高效且绿色的方法，用于在室温下以香蕉皮水提取物（WEB）作为反应介质，通过一锅法由亚苄基丙二腈和吡唑啉酮合成吡喃并[2,3]吡唑。这是一种绿色且通用的合成方法，无需使用任何有毒有机溶剂、配体和碱，适用于广泛的底物范围，产率良好至优异。该方法具有多种优点，如反应速度快、反应条件对环境友好、无需柱色谱即可轻松分离产物。原子经济性反应、环境因子以及过程质量强度等绿色化学指标计算表明该方法具有环境友好的特性。
