Chen Junxiu, Yang Yang, Etim Iniobong P, Tan Lili, Yang Ke, Misra R D K, Wang Jianhua, Su Xuping
Key Laboratory of Materials Surface Science and Technology of Jiangsu Province, Changzhou University, Changzhou 213164, China.
Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, China.
Materials (Basel). 2021 Sep 24;14(19):5550. doi: 10.3390/ma14195550.
The wide application of magnesium alloys as biodegradable implant materials is limited because of their fast degradation rate. Hydroxyapatite (HA) coating can reduce the degradation rate of Mg alloys and improve the biological activity of Mg alloys, and has the ability of bone induction and bone conduction. The preparation of HA coating on the surface of degradable Mg alloys can improve the existing problems, to a certain extent. This paper reviewed different preparation methods of HA coatings on biodegradable Mg alloys, and their effects on magnesium alloys' degradation, biocompatibility, and osteogenic properties. However, no coating prepared can meet the above requirements. There was a lack of systematic research on the degradation of coating samples in vivo, and the osteogenic performance. Therefore, future research can focus on combining existing coating preparation technology and complementary advantages to develop new coating preparation techniques, to obtain more balanced coatings. Second, further study on the metabolic mechanism of HA-coated Mg alloys in vivo can help to predict its degradation behavior, and finally achieve controllable degradation, and further promote the study of the osteogenic effect of HA-coated Mg alloys in vivo.
镁合金作为可生物降解植入材料的广泛应用因降解速率过快而受到限制。羟基磷灰石（HA）涂层可以降低镁合金的降解速率并提高其生物活性，并且具有骨诱导和骨传导能力。在可降解镁合金表面制备HA涂层在一定程度上可以改善现有问题。本文综述了可生物降解镁合金表面HA涂层的不同制备方法，以及它们对镁合金降解、生物相容性和成骨性能的影响。然而，所制备的涂层均无法满足上述要求。目前缺乏对涂层样品体内降解和成骨性能的系统研究。因此，未来的研究可以集中在结合现有涂层制备技术并互补优势以开发新的涂层制备技术，从而获得更具平衡性的涂层。其次，进一步研究HA涂层镁合金在体内的代谢机制有助于预测其降解行为，并最终实现可控降解，进一步推动对HA涂层镁合金体内成骨效果的研究。
