State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, 610500, Sichuan, China; School of Materials Science and Engineering, Southwest Petroleum University, Chengdu, 610500, Sichuan, China.
School of Materials Science and Engineering, Southwest Petroleum University, Chengdu, 610500, Sichuan, China.
Colloids Surf B Biointerfaces. 2019 Apr 1;176:494-506. doi: 10.1016/j.colsurfb.2019.01.038. Epub 2019 Jan 22.
Implants are exposed to a complex physiological environment that contains various organic compounds, especially proteins. The adsorption of proteins has an immense influence on the corrosion, biocompatibility and wear properties of implantable metals. Proteins engage in multiple processes that could potentially inhibit or promote metal degradation, depending on the type of proteins, their concentration and the properties of the implant material. In the bio corrosion process, proteins are denatured and transform into a film on the metal surface, inhibiting corrosion. This film is found on many retrieved artificial joints, especially on worn areas, and can protect the passive film from scrapping due to its lubricating effect, thus decreasing tribocorroion. On the other hand, the interactions of metal ions with proteins (and amino acids) create colloidal organometallic complexes. Transport of the complex compounds away from the interface increases dissolution rates; thus, it accelerates the corrosion of metallic implants. The influence of protein adsorption on the corrosion behaviour of metallic biomaterials is presented in this review. Biocompatible metals that are favourably used as implants such as stainless steel, Co-Cr alloys, Ti alloys and biodegradable Mg and Fe alloys are specifically addressed. We have highlighted the adsorption phenomenon of protein on metallic implants, the interaction of proteins with metallic implants and the role of protein adsorption on implant biocorrosion behaviour as well as their wear resistance.
植入物处于包含各种有机化合物（尤其是蛋白质）的复杂生理环境中。蛋白质的吸附对可植入金属的腐蚀、生物相容性和磨损性能有巨大影响。蛋白质参与多种过程，这些过程可能抑制或促进金属降解，具体取决于蛋白质的类型、浓度和植入材料的性质。在生物腐蚀过程中，蛋白质变性并在金属表面形成一层膜，从而抑制腐蚀。在许多回收的人工关节上都发现了这种薄膜，尤其是在磨损区域，它通过润滑作用保护钝化膜免受刮擦，从而减少摩擦腐蚀。另一方面，金属离子与蛋白质（和氨基酸）的相互作用会形成胶体有机金属配合物。配合物从界面的迁移会增加溶解速率，从而加速金属植入物的腐蚀。本文综述了蛋白质吸附对金属生物材料腐蚀行为的影响。特别针对不锈钢、Co-Cr 合金、钛合金以及可生物降解的 Mg 和 Fe 合金等作为植入物的生物相容性金属进行了讨论。我们强调了蛋白质在金属植入物上的吸附现象、蛋白质与金属植入物的相互作用以及蛋白质吸附对植入物生物腐蚀行为及其耐磨性的作用。
