Khabbaz Bahareh, Solouk Atefeh, Mirzadeh Hamid
Biomedical Engineering Department, Faculty of Engineering, Islamic Azad University Central Tehran Branch, Tehran, 13185/867, Iran.
Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, 15875-4413, Iran.
Prog Biomater. 2019 Sep;8(3):185-196. doi: 10.1007/s40204-019-00120-4. Epub 2019 Sep 24.
Soy protein isolate (SPI), due to its biocompatibility, biodegradability, abundance and being inexpensive, is a suitable polymer for medical applications. In this study, electrospun nanofibrous mats (ENMs) and casting films (CFs), comprising polyvinyl alcohol (PVA)/SPI, were prepared and compared. Both crosslinked ENMs and CFs physical, chemical, mechanical, and biological properties were investigated for wound-healing applications. Considering the importance of exudate absorption by wound dressing the uptake test of all samples was performed in simulated exudate solution. The amount of absorbed exudate, water vapor transmission rate, and mechanical elongation for CFs were 69.243% ± 22.7, 266.7 g/m day, and 2.0825% and increased to 383.33% ± 105.3, 1332.02 g/m day, and 12.292% in the case of ENMs, respectively. There was no significant difference between cell supporting of the two samples due to similar composition and their non-toxic properties. The results showed that ENMs have promising potential in wound-healing applications.
大豆分离蛋白（SPI）因其生物相容性、生物降解性、丰富性和廉价性，是一种适用于医学应用的聚合物。在本研究中，制备并比较了由聚乙烯醇（PVA）/SPI组成的电纺纳米纤维垫（ENM）和流延膜（CF）。研究了交联的ENM和CF的物理、化学、机械和生物学性质在伤口愈合应用中的情况。考虑到伤口敷料吸收渗出液的重要性，在模拟渗出液中对所有样品进行了吸收测试。CF的渗出液吸收量、水蒸气透过率和机械伸长率分别为69.243%±22.7、266.7 g/m·天和2.0825%，而ENM的这些指标分别增至383.33%±105.3、1332.02 g/m·天和12.292%。由于组成相似且无毒，两种样品在细胞支持方面没有显著差异。结果表明，ENM在伤口愈合应用中具有广阔的潜力。
