Nassr Ola Ali, Forsyth Paul
Department of Clinical Pharmacy, College of Pharmacy, Mustansiriya University, Baghdad, Iraq.
NHS Greater Glasgow and Clyde, Pharmacy Services, Clarkston Court, Scotland, United Kingdom.
J Pharm Bioallied Sci. 2019 Jul-Sep;11(3):232-239. doi: 10.4103/jpbs.JPBS_82_19.
Uncontrolled blood pressure (BP) is a major contributor to cardiovascular disease-related morbidity and mortality. However, evidence regarding the rate and factors associated with uncontrolled BP in Iraq is scarce. The objectives of this study were a) to assess the magnitude of and factors associated with patient BP control and b) to investigate the patient-level prescribing patterns of antihypertensive medications, in a large Iraqi hospital.
A prospective, cross-sectional study was conducted in the primary care centers of Al-Yarmouk Hospital in Baghdad, Iraq, between April 2018 and August 2018. Eligible patients answered standard survey questions and had their BP measured. Controlled BP was defined as <130/80mm Hg for patients with diabetes and/or chronic kidney disease and <140/90mm Hg for other populations.
During the study period, 300 patients were included; of which, 67.3% were female. The average age was 57.6 (9.2) years (range, 25-79 years). Among the 300 patients included, only 38.7% had controlled BP. In univariate analysis, poorly controlled BP was not associated with education, employment, smoking, comorbid conditions excluding diabetes, and therapeutic regimen used. In contrast, the strongest predictors of uncontrolled BP were age <60 years, male sex, and diabetes mellitus. The majority were prescribed monotherapy (53.0%), followed by dual therapy (38.7%), and triple therapy (8.3%). Angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors were the most commonly prescribed medications at 74.7%, followed by beta-blockers at 29.3%, calcium channel blockers at 28.0%, and diuretics at 23.0%.
BP control was suboptimal. Effective feasible strategies should be implemented to increase BP control in Iraq to reduce hypertension-related complications.
血压不受控制是心血管疾病相关发病和死亡的主要原因。然而,关于伊拉克血压不受控制的发生率及相关因素的证据很少。本研究的目的是:a)评估患者血压控制的程度及相关因素;b)调查伊拉克一家大型医院中患者层面的抗高血压药物处方模式。
2018年4月至2018年8月期间,在伊拉克巴格达的亚尔穆克医院初级保健中心进行了一项前瞻性横断面研究。符合条件的患者回答标准调查问卷问题并测量血压。糖尿病和/或慢性肾脏病患者的血压控制定义为<130/80mmHg,其他人群为<140/90mmHg。
研究期间纳入300例患者;其中67.3%为女性。平均年龄为57.6(9.2)岁(范围25 - 79岁)。在纳入的300例患者中,只有38.7%的患者血压得到控制。单因素分析中,血压控制不佳与教育程度、就业情况、吸烟、除糖尿病外的合并症以及所用治疗方案无关。相比之下,血压不受控制的最强预测因素是年龄<60岁、男性和糖尿病。大多数患者接受单药治疗(53.0%),其次是联合治疗(38.7%)和三联治疗(8.3%)。血管紧张素II受体阻滞剂或血管紧张素转换酶抑制剂是最常用的药物,占74.7%,其次是β受体阻滞剂,占29.3%,钙通道阻滞剂占28.0%,利尿剂占23.0%。
血压控制不理想。应实施有效的可行策略以提高伊拉克的血压控制水平,从而减少高血压相关并发症。