亲水性和脂溶性他汀类药物治疗对亚洲糖尿病患者长期疗效的不同心血管结局（涉及不同性别）
The Different Cardiovascular Outcomes Between Long-Term Efficacy of Hydrophilic and Lipophilic Statin Therapy in Both Asian Diabetic Sexes.
作者信息
Li Shang-Yi, Chen Hsin-Hung, Lin Cheng-Li, Yeh Su-Yin, Kao Chia-Hung
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua.
Institute of Medicine, Chung Shan Medical University, Taichung.
出版信息
Dose Response. 2019 Sep 16;17(3):1559325819876766. doi: 10.1177/1559325819876766. eCollection 2019 Jul-Sep.
PURPOSE
To evaluate the long-term efficacy of hydrophilic and lipophilic statin therapy for cardiovascular outcomes in Asian diabetic patients.
METHOD
Newly diagnosed cases of type 2 diabetes during the period from January 2000 to December 2011 were divided into 2 cohorts on the basis of their statin use, namely hydrophilic statin and lipophilic statin. We used Cox proportional hazard regression models to analyze the risks of cardiovascular outcomes.
RESULT
In this study, 12 896 patients used statin, including 4259 patients using hydrophilic statin and 8637 patients using lipophilic statin. With 12-year follow-up, higher incidence rate of coronary artery disease and stroke was noted in the lipophilic statin use instead of hydrophilic statin use.
CONCLUSION
According to our long-term cohort study, hydrophilic statin use may be a better choice than lipophilic statin to reduce cardiovascular events in Asian diabetic patients.
目的
评估亲水性他汀类药物和脂溶性他汀类药物治疗对亚洲糖尿病患者心血管结局的长期疗效。
方法
将2000年1月至2011年12月期间新诊断的2型糖尿病病例根据他汀类药物的使用情况分为2组，即亲水性他汀组和脂溶性他汀组。我们使用Cox比例风险回归模型分析心血管结局的风险。
结果
在本研究中，12896例患者使用了他汀类药物，其中4259例患者使用亲水性他汀，8637例患者使用脂溶性他汀。经过12年的随访，发现使用脂溶性他汀而非亲水性他汀的患者冠心病和中风的发病率更高。
结论
根据我们的长期队列研究，在亚洲糖尿病患者中，使用亲水性他汀可能比使用脂溶性他汀更能降低心血管事件的发生。
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