一碳代谢对组蛋白甲基化的影响。
The Impact of One Carbon Metabolism on Histone Methylation.
作者信息
Serefidou Magdalini, Venkatasubramani Anuroop Venkateswaran, Imhof Axel
机构信息
Biomedical Center Munich, Department of Molecular Biology, Ludwig-Maximilians-University Munich, Munich, Germany.
出版信息
Front Genet. 2019 Aug 28;10:764. doi: 10.3389/fgene.2019.00764. eCollection 2019.
Abstract
The effect of one carbon metabolism on DNA methylation has been well described, bridging nutrition, metabolism, and epigenetics. This modification is mediated by the metabolite S-adenosyl methionine (SAM), which is also the methyl-donating substrate of histone methyltransferases. Therefore, SAM levels that are influenced by several nutrients, enzymes, and metabolic cofactors also have a potential impact on histone methylation. Although this modification plays a major role in chromatin accessibility and subsequently in gene expression in healthy or diseased states, its role in translating nutritional changes in chromatin structure has not been extensively studied. Here, we aim to review the literature of known mechanistic links between histone methylation and the central one carbon metabolism.
摘要
一碳代谢对DNA甲基化的影响已得到充分描述，它在营养、代谢和表观遗传学之间架起了桥梁。这种修饰由代谢物S-腺苷甲硫氨酸（SAM）介导，SAM也是组蛋白甲基转移酶的甲基供体底物。因此，受多种营养素、酶和代谢辅助因子影响的SAM水平也可能对组蛋白甲基化产生影响。尽管这种修饰在健康或疾病状态下的染色质可及性以及随后的基因表达中起主要作用，但其在将营养变化转化为染色质结构方面的作用尚未得到广泛研究。在此，我们旨在综述组蛋白甲基化与核心一碳代谢之间已知机制联系的文献。
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