Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada; Department of Basic Sciences in Rehabilitation, School of Rehabilitation Sciences, Iran University of Medical Science (IUMS), Tehran, Iran.
Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada.
Ageing Res Rev. 2019 Dec;56:100963. doi: 10.1016/j.arr.2019.100963. Epub 2019 Sep 23.
Age-related hearing loss (ARHL) or presbycusis, as the third leading cause of chronic disability in older adults, has been shown to be associated with predisposing cognitive impairment and dementia. Tinnitus is also a chronic auditory disorder demonstrating a growth rate with increasing age. Recent evidence stands for the link between bothersome tinnitus and impairments in various aspects of cognitive function. Both ARHL and age-related tinnitus affect mental health and contribute to developing anxiety, stress, and depression. The present review is a comprehensive multidisciplinary study on diverse interactions among ARHL, tinnitus, and cognitive decline in older adults. This review incorporates the latest evidence in prevalence and risk factors of ARHL and tinnitus, the neural substrates of tinnitus-related cognitive impairments, hypothesized mechanisms concerning the association between ARHL and increased risk of dementia, hearing amplification outcomes in cases with ARHL and cognitive decline, and preliminary findings on the link between ARHL and cognitive impairment in animal studies. Given extensive evidence that demonstrates advantages of using auditory amplification in the alleviation of hearing handicap, depression, and tinnitus, and the improvement of cognition, social communication, and quality of life, regular hearing screening programs for identification and management of midlife hearing loss and tinnitus is strongly recommended.
年龄相关性听力损失(ARHL)或老年聋,作为老年人慢性残疾的第三大主要原因,已被证明与易患认知障碍和痴呆有关。耳鸣也是一种慢性听觉障碍,其发病率随年龄增长而增加。最近的证据表明,烦人的耳鸣与认知功能各个方面的损害之间存在联系。ARHL 和与年龄相关的耳鸣都会影响心理健康,并导致焦虑、压力和抑郁的发展。本综述是一项关于老年人中 ARHL、耳鸣和认知衰退之间多种相互作用的综合多学科研究。本综述综合了 ARHL 和耳鸣的患病率和风险因素、耳鸣相关认知障碍的神经基础、ARHL 与痴呆风险增加之间关联的假设机制、ARHL 和认知衰退病例中的听力放大效果以及动物研究中 ARHL 和认知障碍之间关联的初步发现的最新证据。鉴于大量证据表明,听觉放大在减轻听力障碍、抑郁和耳鸣以及改善认知、社交沟通和生活质量方面具有优势,强烈建议对中年听力损失和耳鸣进行常规听力筛查计划,以进行识别和管理。