耳鸣与认知障碍之间的关联：2011 - 2014年美国国家健康与营养检查调查分析
Association between tinnitus and cognitive impairment: analysis of National Health and Nutrition Examination Survey 2011:2014.
作者信息
Wu Jianli, Shi Mengdi, Wang Chao
机构信息
Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Graduate School of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
出版信息
Front Neurol. 2025 May 30;16:1533821. doi: 10.3389/fneur.2025.1533821. eCollection 2025.
BACKGROUND
Tinnitus is one of the most common potential risk factors for cognitive impairment. To understand the relationship between tinnitus and cognitive impairment, the National Health and Nutrition Examination Survey (NHANES) database was analyzed after adjusting for potential confounders, including age and other systemic comorbidities.
MATERIALS AND METHODS
A total of 684 participants who had undergone a total tinnitus survey and underwent a cognitive function test were included. Tinnitus is divided into acute tinnitus and non-acute tinnitus. The Consortium for the Establishment of Alzheimer's Disease Word Learning Xi Registry (CERAD-WL), the Dynamic Logistics Proficiency Test (AFT), and the Digit Sign Substitution Test (DSST) were used to assess cognitive impairment.
RESULTS
Subjects with tinnitus had lower AFT and DSST scores compared to the healthy group, indicating decreased cognitive function. After adjusting for other covariates in humans, tinnitus was significantly associated with a decrease in AFT and DSST scores (trend -values = 0.02 and 0.005, respectively).
CONCLUSION
Tinnitus is associated with cognitive impairment.
背景
耳鸣是认知障碍最常见的潜在风险因素之一。为了解耳鸣与认知障碍之间的关系，在对包括年龄和其他全身性合并症在内的潜在混杂因素进行调整后，对美国国家健康与营养检查调查（NHANES）数据库进行了分析。
材料与方法
共纳入684名接受了全面耳鸣调查并进行了认知功能测试的参与者。耳鸣分为急性耳鸣和非急性耳鸣。使用阿尔茨海默病词汇学习Xi注册协会（CERAD-WL）、动态物流熟练度测试（AFT）和数字符号替换测试（DSST）来评估认知障碍。
结果
与健康组相比，耳鸣患者的AFT和DSST得分较低，表明认知功能下降。在对人类的其他协变量进行调整后，耳鸣与AFT和DSST得分的降低显著相关（趋势值分别为0.02和0.005）。
结论
耳鸣与认知障碍有关。
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