Otorhinolaryngology Head and Neck Surgery Clinic, 147011Health Science University Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
52982Marmara University Vocational School of Health Services, Istanbul, Turkey.
Ear Nose Throat J. 2021 May;100(4):NP198-NP205. doi: 10.1177/0145561319866826. Epub 2019 Sep 26.
Cisplatin-induced ototoxicity is related to oxidative stress. Astaxanthin is one of the most powerful antioxidants in nature.
AIMS/OBJECTIVES: To investigate the protective effect of astaxanthin on cisplatin-induced ototoxicity.
Thirty-five Sprague Dawley female rats were divided into 5 groups: control, cisplatin, and cisplatin with 10, 20, and 40 mg/kg astaxanthin groups. Cisplatin group received a single intraperitoneal injection of 14 mg/kg cisplatin. While saline was administered in the control group, in the other 3 groups, 10, 20, and 40 mg/kg daily doses of astaxanthin were administered through orogastric cannula before administration of cisplatin. Baseline and 10th day otoacoustic emission tests were administered. An intracardiac blood sample was taken to measure total antioxidant capacity (TAC), and the cochleas of the animals were investigated histopathologically.
Hearing level of astaxanthin 40 mg/kg + cisplatin group was higher at 24 kHz and 32 kHz frequencies compared to the cisplatin group. The TAC value of the cisplatin group was lower than both the control and astaxanthin + cisplatin groups ( < .05). On histopathological examination, the other groups were deformed compared to the control group, but no statistically significant difference was observed between the astaxanthin + cisplatin and cisplatin groups.
Astaxanthin showed protective effect at high frequencies when it was administered at high dose. Thus, astaxanthin may have protective effect against cisplatin-induced ototoxicity.
顺铂诱导的耳毒性与氧化应激有关。虾青素是自然界中最有效的抗氧化剂之一。
目的/目标：研究虾青素对顺铂诱导的耳毒性的保护作用。
35 只 Sprague Dawley 雌性大鼠分为 5 组：对照组、顺铂组和 10、20 和 40mg/kg 虾青素组。顺铂组单次腹腔注射 14mg/kg 顺铂。对照组给予生理盐水，其他 3 组在给予顺铂前经口胃管给予 10、20 和 40mg/kg/d 虾青素。进行基线和第 10 天的耳声发射测试。采集心血样测量总抗氧化能力（TAC），并对动物的耳蜗进行组织病理学检查。
与顺铂组相比，虾青素 40mg/kg+顺铂组在 24kHz 和 32kHz 频率下的听力水平更高。顺铂组的 TAC 值低于对照组和虾青素+顺铂组（<0.05）。组织病理学检查发现，其他组与对照组相比变形，但虾青素+顺铂组与顺铂组之间无统计学差异。
高剂量虾青素在高频时表现出保护作用。因此，虾青素可能对顺铂诱导的耳毒性具有保护作用。
