Eden O B, Darbyshire P, Simpson R M, Besley G T, Moss S, Gentle T
Br J Haematol. 1985 Jan;59(1):109-14. doi: 10.1111/j.1365-2141.1985.tb02970.x.
Lysosomal enzyme activities and isoenzyme profiles were measured in lymphoid and non-lymphoid leukaemic cells from childhood patients. High activities, especially of beta-hexosaminidase and alpha-mannosidase, were associated with leukaemic cells of myeloid or monocytic origin. Leukaemic cells from two children with acute myeloid leukaemia had a relative reduction in the B isoenzyme of beta-hexosaminidase activity, whereas in patients with non T, non B cell acute lymphoblastic leukaemia, intermediate beta-hexosaminidase isoenzymes were expressed. A patient is described on whom conventional marker studies were either negative or equivocal, but lysosomal enzyme markers were consistent with a myeloid leukaemia. This observation was supported by the clinical course of this patient.
对儿童患者的淋巴细胞白血病细胞和非淋巴细胞白血病细胞进行了溶酶体酶活性和同工酶谱分析。高活性，尤其是β-己糖胺酶和α-甘露糖苷酶的高活性，与髓系或单核细胞系来源的白血病细胞相关。两名急性髓系白血病患儿的白血病细胞中β-己糖胺酶活性的B同工酶相对减少，而在非T、非B细胞急性淋巴细胞白血病患者中，表达的是中间β-己糖胺酶同工酶。描述了一名患者，其传统标志物研究结果为阴性或不明确，但溶酶体酶标志物与髓系白血病一致。该患者的临床病程支持了这一观察结果。
