Hunter A J, Hole D R, Wilson C A
Pharmacol Biochem Behav. 1985 Jan;22(1):5-13. doi: 10.1016/0091-3057(85)90477-0.
The potential stimulatory and inhibitory effects on female sexual behaviour of five 5HT antagonists and five agents that increase 5HT activity, were noted in ovariectomised rats primed with various steroid regimes such that they were either "receptive" (LQ greater than 50%) or "non-receptive" (LQ less than 50%). The 5HT antagonists cinanserin, mianserin, ketanserin and metergoline all inhibited behaviour in receptive rats. Methysergide and cinanserin stimulated behaviour in non-receptive rats. All the drugs which increased 5HTP activity, i.e., 5HTP, zimelidine, alaproclate, WY 26002 and quipazine stimulated sex behaviour in non-receptive rats. In rats that had been ovariectomised only, part of this effect was probably due to stimulation of adrenal progesterone, but a significant stimulatory effect could still be observed in ovariectomised-adrenalectomised rats. 5HT also had a significant inhibitory effect on receptive rats, and the other agonists showed a similar but non-significant tendency. In view of the fact that 4 out of 5 of the 5HT antagonists inhibited sexual behaviour, we hypothesise that 5HT has a stimulatory role in the control of female sexual behaviour. The possible mechanisms mediating the dual action of 5HTP on female sexual behaviour are discussed.
在接受不同类固醇激素预处理的去卵巢大鼠中，研究了5种5-羟色胺（5HT）拮抗剂和5种增强5HT活性的药物对雌性性行为的潜在刺激和抑制作用，这些大鼠分别处于“接受状态”（ lordosis quotient，LQ大于50%）或“非接受状态”（LQ小于50%）。5HT拮抗剂辛那色林、米安色林、酮色林和麦角乙脲均抑制处于接受状态大鼠的性行为。甲基麦角新碱和辛那色林可刺激处于非接受状态大鼠的性行为。所有增强5-羟色氨酸（5HTP）活性的药物，即5HTP、齐美利定、阿普氯胺、WY 26002和喹哌嗪，均可刺激处于非接受状态大鼠的性行为。仅接受去卵巢手术的大鼠，部分这种效应可能归因于肾上腺孕酮的刺激，但在去卵巢-肾上腺切除大鼠中仍可观察到显著的刺激效应。5HT对处于接受状态的大鼠也有显著抑制作用，其他激动剂也表现出类似但不显著的趋势。鉴于5种5HT拮抗剂中有4种抑制性行为，我们推测5HT在雌性性行为控制中起刺激作用。本文讨论了5HTP对雌性性行为双重作用的可能介导机制。
