Psychology Department, Institute for Health and Sport, Victoria University, Melbourne, Vic., Australia.
Bioscreen Yarraville (Aust) Pty Ltd, Melbourne, Vic., Australia.
Brain Behav. 2019 Nov;9(11):e01408. doi: 10.1002/brb3.1408. Epub 2019 Sep 30.
The prevalence of psychological disorders remains stable despite steady increases in pharmacological treatments suggesting the need for auxiliary treatment options. Consideration of the brain-gut-microbiota axis (BGMA) has made inroads into reconceptualizing psychological illness from a more holistic perspective. While our understanding of the precise role of gut microbiota (GM) in psychological illness is in its infancy, it represents an attractive target for novel interventions.
An extensive review of relevant literature was undertaken.
Gut microbiota are proposed to directly and indirectly influence mood, cognition, and behavior which are key components of mental health. This paper outlines how GM may be implicated in psychological disorders from etiology through to treatment and prevention using the Four P model of case formulation.
Moving forward, integration of GM into the conceptualization and treatment of psychological illness will require the discipline of psychology to undergo a significant paradigm shift. While the importance of the GM in psychological well-being must be respected, it is not proposed to be a panacea, but instead, an additional arm to a multidisciplinary approach to treatment and prevention.
尽管药物治疗不断增加，但心理障碍的患病率仍然保持稳定，这表明需要辅助治疗选择。考虑到脑-肠-微生物群轴（BGMA），人们已经从更全面的角度重新认识心理疾病。虽然我们对肠道微生物群（GM）在心理疾病中的确切作用的理解还处于起步阶段，但它代表了一种有吸引力的新型干预目标。
对相关文献进行了广泛的回顾。
肠道微生物群被认为直接和间接影响情绪、认知和行为，这些是心理健康的关键组成部分。本文概述了 GM 如何通过使用案例制定的四个 P 模型从病因到治疗和预防的角度影响心理障碍。
展望未来，将 GM 纳入心理疾病的概念化和治疗将需要心理学领域发生重大范式转变。虽然 GM 对心理健康的重要性必须得到尊重，但它并不是一种万能药，而是多学科治疗和预防方法的另一种手段。
