Pusceddu Matteo M, Del Bas Josep M
Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Reus, Spain.
Psychiatr Genet. 2020 Aug;30(4):87-100. doi: 10.1097/YPG.0000000000000255.
In recent decades, the concept of the gut microbiota as a potential novel therapeutic strategy for mental health has emerged. The tiny microbes inhabiting our gut communicate through a bidirectional communication signaling with the brain that influences gut physiology, brain function and behavior. Accumulating evidence suggests that perturbation of the gut microbiota contributes to the pathophysiology of mental illnesses including autism, depression and anxiety as well as neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. This review will highlight recent findings in both human and animal studies indicating how changes in the gut microbiota can impact the pathophysiology of such diseases. The current work will also provide an understanding of the efficacy of microbiota-targeted therapies on psychiatric disorders.
近几十年来，肠道微生物群作为一种潜在的心理健康新治疗策略的概念已经出现。生活在我们肠道中的微小微生物通过与大脑的双向通信信号进行交流，这会影响肠道生理、大脑功能和行为。越来越多的证据表明，肠道微生物群的紊乱会导致包括自闭症、抑郁症和焦虑症在内的精神疾病以及如阿尔茨海默病和帕金森病等神经退行性疾病的病理生理过程。这篇综述将重点介绍人类和动物研究中的最新发现，这些发现表明肠道微生物群的变化如何影响此类疾病的病理生理学。当前的研究还将有助于理解针对微生物群的疗法对精神疾病的疗效。
