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癌症相关性乏力、实验室标志物与结直肠癌患者营养状况的关系。

Cancer-Related Fatigue, Laboratory Markers as Indicators for Nutritional Status among Patients with Colorectal Cancer.

机构信息

Faculty of Nursing, Al-Zaytoonah University of Jordan, Amman, Jordan.

出版信息

Nutr Cancer. 2020;72(6):903-908. doi: 10.1080/01635581.2019.1669674. Epub 2019 Oct 1.

Abstract

Our objective was to determine the relationship between cancer-related fatigue (CRF), laboratory markers, and nutritional status among patients with colorectal cancer (CRC). A cross-sectional design was used. A sample of 80 participants diagnosed with CRC participated and completed the study's surveys including the patient-generated subjective global assessment (PG-SGA), cancer fatigue scale (CFS), laboratory markers sheet, and patient-related factors sheet. Positive relationships were identified between PG-SGA and CRF, physical fatigue, cognitive fatigue, WBC, and calcium level ( = 0.781, 0.820, 0.751, 0.680, and 0.710;  = 0.001 respectively). Negative relationships were found between PG-SGA and sodium, potassium, and hemoglobin levels ( = -0.801, -0.761, and -0.810;  = 0.001 respectively). The regression analysis revealed an  = 0.610 (adjusted  = 0.590), (4.58,  < 0.001). Finally, the above-mentioned independent variables accounted for 61.0% of the variance in PG-SGA. Patients with CRC are experiencing nutritional problems during their treatment. Cancer-related fatigue and other laboratory markers are considered indicators for nutritional status. Clinical dietitians and oncology nurses can work together to monitor these parameters and provide clinical treatment when needed.

摘要

我们的目的是确定结直肠癌(CRC)患者的癌症相关疲劳(CRF)、实验室标志物和营养状况之间的关系。采用横断面设计。对 80 名诊断为 CRC 的患者进行了抽样,并完成了研究的调查,包括患者生成的主观整体评估(PG-SGA)、癌症疲劳量表(CFS)、实验室标志物表和患者相关因素表。PG-SGA 与 CRF、身体疲劳、认知疲劳、白细胞计数和钙水平呈正相关( = 0.781、0.820、0.751、0.680 和 0.710;  = 0.001)。PG-SGA 与钠、钾和血红蛋白水平呈负相关( = -0.801、-0.761 和 -0.810;  = 0.001)。回归分析显示  = 0.610(调整后  = 0.590), (4.58,  < 0.001)。最后,上述自变量解释了 PG-SGA 变异的 61.0%。CRC 患者在治疗过程中存在营养问题。癌症相关疲劳和其他实验室标志物被认为是营养状况的指标。临床营养师和肿瘤护士可以共同努力监测这些参数,并在需要时提供临床治疗。

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