Section Acute Medicine, Department of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
PLoS One. 2019 Oct 1;14(10):e0222450. doi: 10.1371/journal.pone.0222450. eCollection 2019.
Due to the rise in incidence, the long term effect of sepsis are becoming more evident. There is increasing evidence that sepsis may result in an impaired health related quality of life. The aim of this study was to investigate whether health related quality of life is impaired in sepsis survivors and which clinical parameters are associated with the affected health related quality of life.
We analyzed 880 Short Form 36 (SF-36) questionnaires that were sent to sepsis survivors who participated in the Prehospital Antibiotics Against Sepsis (PHANTASi) trial. These questionnaires were sent by email, 28 days after discharge. Data entry and statistical analyses were performed in SPSS. The data from the general Dutch population, was obtained from the Netherlands Cancer Institute (NKI-AVL) and served as a control group. Subsequently, 567 sepsis survivors were matched to 567 controls. Non-parametric Wilcoxon signed-rank test was performed to compare these two groups. Within the group, we sought to explain the diminished health related quality of life by factor analysis.
We found that sepsis survivors have a worse health related quality of life compared to the general Dutch population. This negative effect was more evident for the physical component than the mental component of health related quality of life. We found that health related quality of life was significantly altered by advancing age and female sex. We also found that the total length of stay (in the hospital) and (previous) comorbidity negatively affect the physical component of health related quality of life.
In our study we found that health related quality of life in sepsis survivors, 28 days after discharge, is severely diminished in comparison with the general Dutch population. The physical domain is severely affected, whereas the mental domain is less influenced. The length of stay, comorbidity, advancing age and female sex all have a negative effect on the Physical Component Scale of the health related quality of life.
由于发病率的上升，败血症的长期影响变得更加明显。越来越多的证据表明，败血症可能导致健康相关生活质量受损。本研究旨在调查败血症幸存者的健康相关生活质量是否受损，以及哪些临床参数与受影响的健康相关生活质量相关。
我们分析了 880 份短格式 36 项健康调查（SF-36）问卷，这些问卷是发送给参加院前抗生素治疗败血症（PHANTASi）试验的败血症幸存者的。这些问卷通过电子邮件发送，在出院后 28 天发送。数据录入和统计分析在 SPSS 中进行。一般荷兰人群的数据是从荷兰癌症研究所（NKI-AVL）获得的，并作为对照组。随后，将 567 名败血症幸存者与 567 名对照者进行匹配。采用非参数 Wilcoxon 符号秩检验比较两组数据。在组内，我们试图通过因子分析来解释健康相关生活质量的下降。
我们发现败血症幸存者的健康相关生活质量比一般荷兰人群差。这种负面影响在健康相关生活质量的生理成分上比心理成分更为明显。我们发现，健康相关生活质量明显受到年龄增长和女性性别影响。我们还发现，总住院时间（住院时间）和（既往）合并症会对健康相关生活质量的生理成分产生负面影响。
在我们的研究中，我们发现出院后 28 天的败血症幸存者的健康相关生活质量严重下降，与一般荷兰人群相比明显受损。生理领域受到严重影响，而心理领域受到的影响较小。住院时间、合并症、年龄增长和女性性别都对健康相关生活质量的生理成分产生负面影响。
