Research Center for Human Tissue and Organs Degeneration, Institute Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
J Mater Chem B. 2019 Nov 14;7(42):6488-6499. doi: 10.1039/c9tb01521c. Epub 2019 Oct 2.
Surgical sealants suitable for wounds with non-flat complex geometries are still a challenge to fulfill clinical requirements. Herein, a novel fit-to-shape sealant enhanced by photo-initiated crosslinking was developed utilizing maleic anhydride modified chitosan (MCS), benzaldehyde-terminated PEG (PEGDF) and polyethylene glycol diacrylate (PEGDA). Initially, the shear-thinning hydrogel prepared through the Schiff-base linkage between MCS and PEGDF could be injected into target sites, remolded to conform to a wound with non-flat complex geometry, and remain on the wound, avoiding adverse liquid leakage. Under illumination with ultra-violet (UV) light, the hydrogel was solidified in situ rapidly to adopt the wound contour and enhanced in adhesive strength to seal defects of the tissue. In addition, the hydrogel exhibits stability in extreme pH environments (pH = 1) and has potential to treat wounds inside the stomach with the existence of gastric acid. Moreover, the hydrogel can be applied as adhesive wound dressings through in situ 3D printing. Taken together, the fit-to-shape sealant enhanced by photo-initiated crosslinking can be considered as promising tissue adhesives for wound closure and other biomedical applications.
适用于非平整复杂几何形状伤口的外科密封剂仍然难以满足临床需求。在此，利用马来酸酐改性壳聚糖（MCS）、苯甲醛封端的聚乙二醇（PEGDF）和聚乙二醇二丙烯酸酯（PEGDA），开发了一种通过光引发交联增强的形状适应性密封剂。首先，通过 MCS 和 PEGDF 之间的席夫碱键合制备的剪切稀化水凝胶可以注入目标部位，重塑为与非平整复杂几何形状的伤口贴合，并留在伤口上，避免不良的液体泄漏。在紫外（UV）光照射下，水凝胶原位快速固化，以适应伤口轮廓，并增强其粘附强度以密封组织缺陷。此外，该水凝胶在极端 pH 环境（pH = 1）下稳定，并且有可能在存在胃酸的情况下治疗胃内的伤口。此外，该水凝胶可以通过原位 3D 打印用作粘性伤口敷料。综上所述，通过光引发交联增强的形状适应性密封剂可以被认为是用于伤口闭合和其他生物医学应用的有前途的组织粘合剂。
