Department of Ophthalmology, School of Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University, Changwon, Republic of Korea.
Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Eur J Ophthalmol. 2020 Nov;30(6):NP21-NP26. doi: 10.1177/1120672119872364. Epub 2019 Oct 3.
contains hydroxycitric acid. Hydroxycitric acid is a potent competitive inhibitor of adenosine triphosphate citrate lyase which is a key enzyme in the synthesis of fatty acids. Hydroxycitric acid also regulates the level of serotonin. In these regards, hydroxycitric acid has been reported to exhibit weight loss activity. Adverse reactions of from numerous clinical studies demonstrated relatively mild reactions. However, there are some complications of reported in the past: acute liver injury, acute hepatitis, and hepatic failure. However, ocular complications of have not been reported yet.
A 35-year-old female visited our clinic with decreased vision in the left eye and ocular pain in both eyes for the last 6 days. She also complained of headache, dizziness, and nausea. She had taken extract more than the recommended dose. There was myopic shift with anterior chamber shallowing in both eyes, especially in the left eye. Moreover, swelling and retinal folds of peripapillary retinal nerve fiber layer and macula were observed in both eyes. These ocular complications of extract resolved after discontinuation of the extract and topical and oral steroid treatment. Herein, we report the first case of ocular complications of extract diet pill assessed with optical coherence tomography of optic disk and macula along with dual Scheimpflug analyzer.
It is necessary that physicians dealing with obesity advice patients about possible visual disturbance of this extract when taken in overdose so that they can see an ophthalmologist immediately.
包含羟基柠檬酸。羟基柠檬酸是三磷酸柠檬酸裂解酶的一种强有力的竞争性抑制剂，三磷酸柠檬酸裂解酶是脂肪酸合成的关键酶。羟基柠檬酸还调节血清素的水平。在这些方面，羟基柠檬酸已被报道具有减肥活性。来自许多临床研究的不良反应表明相对温和的反应。然而，过去有报道称存在一些[成分名称]的并发症：急性肝损伤、急性肝炎和肝衰竭。然而，尚未报道[成分名称]的眼部并发症。
一位 35 岁女性因左眼视力下降和双眼眼痛就诊，持续了 6 天。她还主诉头痛、头晕和恶心。她曾服用[成分名称]提取物超过推荐剂量。双眼前房变浅，尤其是左眼。此外，双眼视盘和黄斑周围的视网膜神经纤维层和黄斑均出现肿胀和视网膜皱褶。停用提取物并进行局部和口服类固醇治疗后，这些[成分名称]提取物的眼部并发症得到缓解。在此，我们报告了首例使用光学相干断层扫描（OCT）评估视盘和黄斑以及双 Scheimpflug 分析仪评估[成分名称]提取物减肥药引起的眼部并发症的病例。
处理肥胖症的医生有必要告知患者服用这种提取物过量可能会出现视力障碍，以便他们可以立即看眼科医生。
