Tavangar Atefeh, Aslani Abolfazl, Nikbakht Niloofar
Dental Material Research Center, Dept. of Oral and Maxillofacial Medicine, Dental Research Institute,Isfahan University of Medical Sciences, Isfahan,Iran.
Dept. of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Dent (Shiraz). 2019 Sep;20(3):184-189. doi: 10.30476/DENTJODS.2019.44913.
Recurrent aphthous stomatitis is a common oral lesion, and the use of herbal remedies containing tannin and flavonoid has been reported to be effective in treating aphthous stomatitis.
This study was aimed to evaluate the effect of muco-adhesive gel on controlling the oral recurrent aphthous stomatitis and its comparison with Triadent oral paste.
In this double-blind clinical trial, 60 patients with minor aphthous stomatitis were enrolled. These patients had no systemic diseases and were not on any medications. The patients were randomly treated with formulated gel, Triadent oral paste and placebo. The time of pain elimination and the time of complete healing were recorded and the pain degree was assessed and recorded by each patient. The data were analyzed using survival analysis and ANOVA test.
The Kaplan-Meier survival analysis demonstrated that pain relief time in group was lower than placebo group (= 0.002), even so, it caused no significant difference with the Triadent group in comparison with the placebo group (= 0.08). The survival analysis also indicated that the wound healing time in group was significantly lower than the other two groups (< 0.05).
gel has a successful effect in controlling and treating recurrent aphthous stomatitis. It can be considered as an affordable and inexpensive treatment.
复发性阿弗他口炎是一种常见的口腔病变，据报道，使用含有单宁和类黄酮的草药疗法对治疗阿弗他口炎有效。
本研究旨在评估黏膜黏附凝胶对控制复发性阿弗他口炎的效果及其与Triadent口腔糊剂的比较。
在这项双盲临床试验中，招募了60例轻度阿弗他口炎患者。这些患者没有全身性疾病，也未服用任何药物。患者被随机给予配制的凝胶、Triadent口腔糊剂和安慰剂。记录疼痛消除时间和完全愈合时间，每位患者评估并记录疼痛程度。使用生存分析和方差分析检验对数据进行分析。
Kaplan-Meier生存分析表明，[未提及的实验组]组的疼痛缓解时间低于安慰剂组（P = 0.002），即便如此，与安慰剂组相比，它与Triadent组相比无显著差异（P = 0.08）。生存分析还表明，[未提及的实验组]组的伤口愈合时间明显低于其他两组（P < 0.05）。
[未提及的实验组]凝胶在控制和治疗复发性阿弗他口炎方面有成功的效果。它可被视为一种经济实惠的治疗方法。
