Rezvani Zeinab, Cheshme Soltani Masoume Tork, Mirzadeh Monirsadat, Gheibi Nematollah, Mokhlesi Aida, Zarabadipour Mahdieh
Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Community Medicine, Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University Of Medical Sciences, Qazvin, Iran; USERN Office, Qazvin University of Medical Sciences, Qazvin, Iran.
Int Dent J. 2025 Apr;75(2):921-925. doi: 10.1016/j.identj.2024.09.008. Epub 2024 Oct 8.
Recurrent aphthous stomatitis (RAS) is a common oral mucosal lesion. Herbal medicine has been explored to treat this condition. This study compared the effectiveness of two oral pastes containing Triamcinolone and Sumac, for the healing, size, and symptomatology of RAS.
This triple-blind randomized clinical trial included 60 patients with minor aphthous ulcers. Participants were informed about the study and provided consent. Exclusion criteria consisted of specific medical conditions and medication use. The patients were divided into three groups and received either Sumac adhesive gel, Triadent oral paste, or a placebo. Ulcer size was measured before and after treatment. The medication was prepared using carboxymethylcellulose-based gel and Sumac powder extract. The study was triple-blinded, and the groups were labelled as A, B, and C. Data analysis was performed using SPSS version 22, employing repeated measurement, student t test, Kolmogorov-Smirnoff, and one-way ANOVA for quantitative data. Statistical significance was set at P ≤ .05.
A clinical trial involving 59 participants compared the Sumac, Triadent, and placebo groups. The Sumac group exhibited the shortest healing time, significantly reduced lesion size, and lower Visual Analog Scale scores. Triadent took the longest time to heal ulcers. ANOVA test indicated no significant difference in age and gender distribution.
This clinical trial evaluated two oral pastes for treating aphthous ulcers and found that the Sumac group achieved faster healing and reduced lesion size compared to the Triadent and control groups. Sumac shows promise as a treatment option, but further studies are necessary to confirm its efficacy and safety. These favourable results support the use of herbal treatments and suggest their potential for broader utilization in managing diseases such as RAS.
复发性阿弗他口炎（RAS）是一种常见的口腔黏膜病变。人们一直在探索用草药来治疗这种疾病。本研究比较了两种含曲安奈德和漆树的口腔糊剂对RAS愈合情况、溃疡大小和症状的疗效。
这项三盲随机临床试验纳入了60例轻型阿弗他溃疡患者。向参与者介绍了该研究并获得了他们的同意。排除标准包括特定的医疗状况和药物使用情况。患者被分为三组，分别接受漆树黏附凝胶、Triadent口腔糊剂或安慰剂。在治疗前后测量溃疡大小。药物是用羧甲基纤维素基凝胶和漆树粉末提取物制备的。该研究为三盲试验，各组标记为A、B和C。使用SPSS 22版进行数据分析，对定量数据采用重复测量、学生t检验、柯尔莫哥洛夫-斯米尔诺夫检验和单因素方差分析。统计学显著性设定为P≤0.05。
一项涉及59名参与者的临床试验比较了漆树组、Triadent组和安慰剂组。漆树组愈合时间最短，病变大小显著减小，视觉模拟量表评分更低。Triadent组愈合溃疡所需时间最长。方差分析表明年龄和性别分布无显著差异。
这项临床试验评估了两种治疗阿弗他溃疡的口腔糊剂，发现与Triadent组和对照组相比，漆树组愈合更快，病变大小减小。漆树显示出作为一种治疗选择的前景，但需要进一步研究来证实其疗效和安全性。这些良好结果支持使用草药治疗，并表明它们在管理RAS等疾病方面有更广泛应用的潜力。
