Department of Oncology, Changzhou Traditional Chinese Medical Hospital, Changzhou, Jiangsu 213003, PR China.
Department of Oncology, Jining Cancer Hospital, Jining, Shandong 272000, PR China.
Future Oncol. 2019 Oct;15(30):3467-3481. doi: 10.2217/fon-2018-0879. Epub 2019 Oct 3.
Cervical cancer is one of the leading causes of cancer mortality in women. Peripheral white blood cell parameters such as neutrophil (NE), eosinophil (EO), basophil (BA), as well as lymphocyte (LY) and monocyte (MO), are correlated with tumor outcomes. In total, 110 cervical squamous cell carcinoma patients were recruited in this study. The potential prognostic factors were evaluated by univariate and multivariate survival analysis. Cox regression analysis model indicated that higher pretreatment EO level and increased post-/preradiotherapy EO ratio were independently associated with worse progression-free survival. Lower pretreatment LY or higher EO levels and increased post-/preradiotherapy EO ratio were independently associated with worse overall survival. LY and EO are correlated with outcomes of cervical squamous cell cancer.
宫颈癌是导致女性癌症死亡的主要原因之一。外周血白细胞参数，如中性粒细胞（NE）、嗜酸性粒细胞（EO）、嗜碱性粒细胞（BA），以及淋巴细胞（LY）和单核细胞（MO），与肿瘤预后相关。本研究共纳入 110 例宫颈鳞状细胞癌患者。通过单因素和多因素生存分析评估潜在的预后因素。Cox 回归分析模型表明，较高的预处理 EO 水平和放疗后/前 EO 比值的增加与无进展生存期较差独立相关。较低的预处理 LY 或较高的 EO 水平和放疗后/前 EO 比值的增加与总生存期较差独立相关。LY 和 EO 与宫颈鳞状细胞癌的预后相关。
