Prokopenko L G
Zh Mikrobiol Epidemiol Immunobiol. 1985 Mar(3):86-91.
The present study has been made on (CBA X C57BL)F1 mice immunized with sheep red blood cells (SRBC) and inoculated with staphylococci (M-SRBC-S). The injection of splenic lymphocytes from syngeneic M-SRBC-S into intact mice has been found to suppress immune response to SRBC in these mice. The injection of trypsin into M-SRBC-S decreases the suppressive action of their lymphocytes on SRBC-induced immune response in syngeneic recipients. The injection of trypsin into the recipients has been found to produce no effect on the immunosuppressive action of transplanted lymphocytes obtained from M-SRBC-S. The injection of trypsin into M-SRBC-S induces the release of the factor, inhibiting the formation and function of suppressor cells, by their splenocytes. Previously formed suppressor cells block the release of the immunostimulating factor by the splenocytes of the animals receiving the injections of trypsin.
本研究以用绵羊红细胞（SRBC）免疫并接种葡萄球菌（M-SRBC-S）的（CBA×C57BL）F1小鼠为对象。已发现将同基因M-SRBC-S的脾淋巴细胞注射到未受处理的小鼠体内可抑制这些小鼠对SRBC的免疫反应。向M-SRBC-S中注射胰蛋白酶可降低其淋巴细胞对同基因受体中SRBC诱导的免疫反应的抑制作用。已发现向受体注射胰蛋白酶对从M-SRBC-S获得的移植淋巴细胞的免疫抑制作用没有影响。向M-SRBC-S中注射胰蛋白酶可诱导其脾细胞释放抑制抑制细胞形成和功能的因子。先前形成的抑制细胞会阻止接受胰蛋白酶注射的动物的脾细胞释放免疫刺激因子。
