Chongqing Key Laboratory of Green Synthesis and Application, Active Carbohydrate Research Institute, Chongqing Normal University , Chongqing , China.
J Enzyme Inhib Med Chem. 2019 Dec;34(1):1590-1596. doi: 10.1080/14756366.2019.1655406.
Oral colon administration system has become a new method to treat intestinal diseases. The implementation of colon drug delivery system is restricted by many aspects, including physical and chemical properties, drug delivery mode, gastrointestinal physiological factors, and so on. Delivery methods to overcome these challenges revolve around the mechanisms of drug delivery, including the use of rational dosage forms to avoid the complex pH environment, and the prevention of drug release and absorption in the upper digestive tract.
口服结肠给药系统已成为治疗肠道疾病的一种新方法。结肠药物传递系统的实施受到许多因素的限制，包括物理化学性质、药物传递方式、胃肠道生理因素等。克服这些挑战的传递方法围绕着药物传递机制展开，包括使用合理的剂型来避免复杂的 pH 环境，以及防止药物在上消化道中的释放和吸收。
