Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with The Division of Laboratory Medicine, Białystok, Poland.
Clinical Research Centre, Medical University of Białystok, Białystok, Poland.
Med Sci Monit. 2023 Jun 12;29:e940119. doi: 10.12659/MSM.940119.
BACKGROUND Pharmacogenomics (PGx) has a direct influence on personalized drug therapy for various types of disorders and has been proven to have an important role in the future of medicine. The present study evaluated the awareness of PGx testing of clinicians and healthcare workers in the Republic of Poland. To the best of our knowledge, this is the first direct assessment of Polish healthcare professionals' attitudes toward introducing PGx tests into daily clinical practice. MATERIAL AND METHODS We used a comprehensive anonymous questionnaire with queries on level of education, background knowledge of PGx tests, advantages and barriers for implementation of such tests, and clinicians' desire to order the test that was distributed online to doctors, healthcare workers, related students/Ph.D. students, and administrative staff managing healthcare units. RESULTS We gathered 315 responses. According to the answers, two-thirds of participants had heard about PGx before (64.4%). An overwhelming majority of respondents appreciated the benefits of PGx (93.3%). Indeed, prior knowledge and level of education showed significant associations with positive attitudes toward PGx clinical testing (P≤0.05). However, all participants agreed there are major challenges for including such tests as part of routine clinical practice. CONCLUSIONS While the awareness and interest in PGx clinical testing in Polish healthcare providers are rising, some main barriers for implementation of these tests still need to be addressed in Poland.
药物基因组学（PGx）对各种类型疾病的个体化药物治疗有直接影响，并且已被证明在未来的医学中具有重要作用。本研究评估了波兰临床医生和医疗保健工作者对 PGx 检测的认识。据我们所知，这是首次直接评估波兰医疗保健专业人员对将 PGx 测试引入日常临床实践的态度。
我们使用了一份全面的匿名问卷，其中包含有关教育水平、PGx 测试背景知识、实施此类测试的优势和障碍以及临床医生对订购该测试的意愿的查询，该问卷在线分发给医生、医疗保健工作者、相关学生/博士生和管理医疗单位的行政人员。
我们共收集了 315 份回复。根据回答，三分之二的参与者之前听说过 PGx（64.4%）。绝大多数受访者赞赏 PGx 的益处（93.3%）。事实上，先前的知识和教育水平与对 PGx 临床检测的积极态度呈显著相关（P≤0.05）。然而，所有参与者都认为将此类测试纳入常规临床实践存在重大挑战。
尽管波兰医疗保健提供者对 PGx 临床检测的认识和兴趣正在上升，但在波兰仍需要解决一些实施这些测试的主要障碍。
