Division of Geriatrics, Department of Internal Medicine, Erciyes School of Medicine, Erciyes University, 38090, Melikgazi, Kayseri, Turkey.
Department of Neurology, Erciyes School of Medicine, Erciyes University, 38090, Melikgazi, Kayseri, Turkey.
Neurol Sci. 2020 Feb;41(2):313-320. doi: 10.1007/s10072-019-04073-1. Epub 2019 Oct 3.
BACKGROUND/AIM: To assess sarcopenia and dynapenia and their relationship with disease severity and disabilities in PD and to state body composition in PD.
We conducted a case-control, cross-sectional study that included 70 patients with idiopathic PD and 85 controls. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. Dynapenia was detected by a handheld dynamometer. Bioimpedance analysis (BIA) was performed, and the SARC-F questionnaire was applied. Disabilities were appointed according to the Katz and Lawton indexes.
Sarcopenia and dynapenia were more prevalent in PD than in controls (50 vs 30.6% and 31.4 vs 17.6%, respectively). Dynapenia was significantly associated with the severity of the disease and disabilities (p = 0.047, p = 0.001); however, sarcopenia was not. The skeletal muscle mass index (SMMI), fat mass index (FMI), and fat-free mass index (FFMI) did not differ between the PD and controls. FMI was lower in the advanced stages of the disease. Higher scores in the SARC-F questionnaire were significantly associated with disabilities and the severity of the disease (p < 0.001, p < 0.001).
Muscle strength was closely associated with the severity of the disease and disabilities in PD, but muscle mass was not. Sarcopenia, defined by the SARC-F questionnaire, was a good predictor of disabilities in PD, while the EWGSOP criteria were not. PD patients have a favorable body composition even in advanced stages of the disease with lower FMI and protected lean mass.
背景/目的：评估 PD 患者的肌肉减少症和力量衰减症及其与疾病严重程度和残疾的关系，并描述 PD 患者的身体成分。
我们进行了一项病例对照、横断面研究，纳入了 70 名特发性 PD 患者和 85 名对照。根据欧洲老年人肌肉减少症工作组（EWGSOP）标准定义肌肉减少症。使用手持测力计检测力量衰减症。进行生物电阻抗分析（BIA）和 SARC-F 问卷评估。根据 Katz 和 Lawton 指数指定残疾。
与对照组相比，PD 患者中肌肉减少症和力量衰减症更为常见（50%比 30.6%和 31.4%比 17.6%）。力量衰减症与疾病严重程度和残疾显著相关（p=0.047，p=0.001），而肌肉减少症则不然。PD 患者和对照组的骨骼肌质量指数（SMMI）、脂肪质量指数（FMI）和无脂肪质量指数（FFMI）无差异。疾病晚期的 FMI 较低。SARC-F 问卷的较高分数与残疾和疾病严重程度显著相关（p<0.001，p<0.001）。
肌肉力量与 PD 患者的疾病严重程度和残疾密切相关，但肌肉质量则不然。SARC-F 问卷定义的肌肉减少症是 PD 患者残疾的良好预测指标，而 EWGSOP 标准则不是。即使在疾病晚期，PD 患者的身体成分仍较好，FMI 较低，瘦体重得到保护。
