MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Medical and Research Center, University of Tokyo, Tokyo, Japan.
Aging Clin Exp Res. 2023 Dec;35(12):3097-3104. doi: 10.1007/s40520-023-02614-5. Epub 2023 Nov 10.
Muscle weakness is associated with adverse clinical outcomes including disability and mortality. We report demographic, anthropometric and lifestyle correlates of grip strength in UK and Japanese population-based cohorts.
To report prevalence of low grip strength according to 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and 2019 Asian Working Group for Sarcopenia (AWGS 2019) thresholds and to consider correlates of grip strength in Eastern and Western populations.
UK (1572 men; 1415 women) and Japanese (519 men; 1027 women) participants were recruited from two cohorts harmonised by consensus. Muscle strength was measured by grip strength dynamometry. Potential correlates of grip strength were examined using sex-stratified linear regression; univariate correlates (p < 0.05) were included in mutually adjusted models.
Mean (SD) age was 66.2 (2.8) and 65.8 (12.3) in UK and Japanese cohorts, respectively. Prevalence of low grip strength was higher in Japanese participants (EWGSOP2 5.4% versus 2.4%, AWGS 2019 9.0% versus 3.7%). In both cohorts and sexes, univariate correlates of lower grip strength were older age, shorter height, not consuming alcohol, leaving education earlier and greater comorbidity. Apart from older age and shorter height, the only factors related to lower grip strength in mutually adjusted analyses were greater comorbidity among UK participants (kg difference in grip strength (95%CI) per additional comorbidity - 0.60(- 0.98, - 0.21) among men and - 0.50(- 0.86, - 0.13) among women) and not consuming alcohol among Japanese men (- 1.33(- 2.51, - 0.15)).
Correlates of muscle strength were similar in both cohorts.
A global approach to age-related muscle weakness prevention may be appropriate.
肌肉无力与不良临床结局相关，包括残疾和死亡。我们报告了英国和日本基于人群的队列中握力的人口统计学、人体测量学和生活方式相关因素。
根据 2019 年欧洲老年人肌肉减少症工作组（EWGSOP2）和 2019 年亚洲肌肉减少症工作组（AWGS 2019）标准报告低握力的患病率，并考虑东西方人群握力的相关因素。
从两个通过共识协调的队列中招募了英国（1572 名男性；1415 名女性）和日本（519 名男性；1027 名女性）参与者。肌肉力量通过握力测力计测量。使用性别分层线性回归分析握力的潜在相关因素；将具有统计学意义的（p<0.05）单变量相关因素纳入相互调整的模型中。
英国和日本队列参与者的平均（SD）年龄分别为 66.2（2.8）和 65.8（12.3）岁。日本参与者的低握力患病率更高（EWGSOP2 为 5.4%，而英国为 2.4%；AWGS 2019 为 9.0%，而英国为 3.7%）。在两个队列和性别中，握力较低的单变量相关因素为年龄较大、身高较矮、不饮酒、提前离开教育和共病更多。除了年龄较大和身高较矮之外，相互调整分析中与握力较低相关的唯一因素是英国参与者的共病更多（握力差异（95%CI）每增加一种共病男性为 0.60（-0.98，-0.21），女性为 0.50（-0.86，-0.13））和日本男性不饮酒（-1.33（-2.51，-0.15））。
两个队列中肌肉力量的相关因素相似。
可能需要采取全球方法预防与年龄相关的肌肉无力。
