New Pyridinium Compound from Marine Sediment-Derived Bacterium S-1.

The structural diversity of marine natural products is considered a potential resource for the pharmaceutical industry. In our study of marine-derived compounds, one bacterium S-1 was discovered to have the ability to produce bioactive natural products. After a further chemistry investigation, one novel 4-aminopyridinium derivative, 4-(dimethylamino)-1-(2-((4hydroxybenzoyl)oxy)propyl)pyridin-1-ium (), along with 15 known cyclic dipeptides (-) were isolated from the bacterium S-1 derived from a shallow sea sediment. The structures of compounds - were elucidated through comprehensive NMR spectroscopic and specific optical rotation (OR) data analyses. Compound showed antibacterial activity against with an MIC value of 50 µg/mL. This is the first study to discover a pyridinium derivative and cyclic dipeptides from