State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, China.
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China.
J Antibiot (Tokyo). 2019 Oct;72(10):752-758. doi: 10.1038/s41429-019-0209-5. Epub 2019 Jul 19.
Two new diketopiperazines (1, 2), one new polyprenol (3), together with 19 known compounds (4-22) were obtained from the EtOAc extract of Bionectria sp. Y1085, an endophytic fungus isolated from the plant Huperzia serrata. Their structures were elucidated by extensive NMR and MS analysis. Bionectin D (1) is a rare diketopiperazine with a single methylthio substitution at the α-carbon of cyclized amino acid residue. The antibacterial activity of compounds was assayed against Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium ATCC 6539, and some metabolites (1, 2, 10, 11, and 14) exhibited evident antibacterial activity.
从内生真菌 Bionectria sp. Y1085 的乙酸乙酯提取物中分离得到两种新的二酮哌嗪（1、2）、一种新的多萜醇（3）以及 19 种已知化合物（4-22）。通过广泛的 NMR 和 MS 分析确定了它们的结构。Bionectin D（1）是一种罕见的二酮哌嗪，其环化氨基酸残基的α-碳上有一个单甲基硫取代基。对化合物的抗菌活性进行了测定，结果表明，部分代谢物（1、2、10、11 和 14）对大肠杆菌、金黄色葡萄球菌和鼠伤寒沙门氏菌 ATCC 6539 具有明显的抗菌活性。
