单光子 DNA 光解在 830nm 由喹啉二碳菁染料。
Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes.
机构信息
Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
出版信息
Chem Commun (Camb). 2019 Oct 17;55(84):12667-12670. doi: 10.1039/c9cc04751d.
Abstract
We have synthesized symmetrical carbocyanine dyes in which two 4-quinolinium rings are joined by a pentamethine bridge that is meso-substituted with H or Cl. Irradiation of the halogenated dye at 830 nm produces hydroxyl radicals that generate DNA direct strand breaks. This represents the first reported example of DNA photocleavage upon single photon excitation of a chromophore at wavelengths above 800 nm.
摘要
我们合成了对称的碳菁染料，其中两个 4-喹啉鎓环通过一个五甲川桥连接，桥的中位被 H 或 Cl 取代。卤化染料在 830nm 处辐照会产生羟基自由基，从而导致 DNA 直接链断裂。这代表了在波长大于 800nm 的单光子激发发色团时，DNA 光裂解的首例报道。
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