LncRNA2Target v2.0：一个综合性的数据库，包含人类和小鼠中 lncRNA 的靶基因。
LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse.
机构信息
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
出版信息
Nucleic Acids Res. 2019 Jan 8;47(D1):D140-D144. doi: 10.1093/nar/gky1051.
Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification of target genes of lncRNAs. However, no online repository is available to collect the information on target genes regulated by lncRNAs. To make it convenient for researchers to know what genes are regulated by a lncRNA of interest, we developed a database named lncRNA2Target to provide a comprehensive resource of lncRNA target genes in 2015. To update the database this year, we retrieved all new lncRNA-target relationships from papers published from 1 August 2014 to 30 April 2018 and RNA-seq datasets before and after knockdown or overexpression of a specific lncRNA. LncRNA2Target database v2.0 provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene, and is freely accessible at http://123.59.132.21/lncrna2target.
长链非编码 RNA（lncRNA）在调节基因表达中发挥着关键作用，越来越多的研究人员专注于鉴定 lncRNA 的靶基因。然而，目前还没有在线数据库可以收集 lncRNA 调控的靶基因信息。为了方便研究人员了解特定 lncRNA 调控哪些基因，我们于 2015 年开发了一个名为 lncRNA2Target 的数据库，提供了一个 lncRNA 靶基因的综合资源。为了在今年更新数据库，我们从 2014 年 8 月 1 日至 2018 年 4 月 30 日发表的论文和特定 lncRNA 敲低或过表达前后的 RNA-seq 数据集检索到所有新的 lncRNA-靶关系。lncRNA2Target 数据库 v2.0 通过一个网络界面提供服务，用户可以通过该界面搜索特定 lncRNA 的靶基因，或搜索靶向特定基因的 lncRNA，该数据库可在 http://123.59.132.21/lncrna2target 免费获取。
Zotero 插件