Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos, São Paulo, Brazil.
University Center of the Guaxupé Education Foundation (UNIFEG), Guaxupé, Minas Gerais, Brazil.
J Biomed Mater Res A. 2021 Sep;109(9):1765-1775. doi: 10.1002/jbm.a.37170. Epub 2021 Mar 17.
In general, bone fractures are able of healing by itself. However, in critical situations such as large bone defects, poor blood supply or even infections, the biological capacity of repair can be impaired, resulting in a delay of the consolidation process or even in non-union fractures. Thus, technologies able of improving the process of bone regeneration are of high demand. In this context, ceramic biomaterials-based bone substitutes and photobiomodulation (PBM) have been emerging as promising alternatives. Thus, the present study performed a systematic review targeting to analyze studies in the literature which investigated the effects of the association of ceramic based bone substitutes and PBM in the process of bone healing using animal models of bone defects. The search was conducted from March and April of 2019 in PubMed, Web of Science and Scopus databases. After the eligibility analyses, 16 studies were included in this review. The results showed that the most common material used was hydroxyapatite (HA) followed by Biosilicate associated with infrared PBM. Furthermore, 75% of the studies demonstrated positive effects to stimulate bone regeneration from association of ceramic biomaterials and PBM. All studies used low-level laser therapy (LLLT) device and the most studies used LLLT infrared. The evidence synthesis was moderate for all experimental studies for the variable histological analysis demonstrating the efficacy of techniques on the process of bone repair stimulation. In conclusion, this review demonstrates that the association of ceramic biomaterials and PBM presented positive effects for bone repair in experimental models of bone defects.
一般来说，骨折能够自行愈合。然而，在一些严重的情况下，如大的骨缺损、血液供应不良甚至感染，修复的生物能力可能会受到损害，导致愈合过程延迟，甚至出现骨折不愈合。因此，能够改善骨再生过程的技术有很高的需求。在这方面，基于陶瓷的骨替代材料和光生物调节（PBM）已经成为有前途的替代方法。因此，本研究进行了一项系统评价，旨在分析文献中研究基于陶瓷的骨替代材料和 PBM 联合应用于骨缺损动物模型中骨愈合过程的研究。检索于 2019 年 3 月至 4 月在 PubMed、Web of Science 和 Scopus 数据库中进行。经过资格分析，有 16 项研究纳入本综述。结果表明，最常用的材料是羟基磷灰石（HA），其次是与红外 PBM 相关的生物硅。此外，75%的研究表明，陶瓷生物材料与 PBM 联合使用能刺激骨再生。所有研究都使用低水平激光疗法（LLLT）设备，大多数研究使用红外 LLLT。所有实验研究的证据综合评价均为中度，因为组织学分析变量表明这些技术在刺激骨修复过程中的有效性。总之，本综述表明，陶瓷生物材料和 PBM 的联合应用对骨缺损实验模型中的骨修复有积极的影响。
