Physics and Astronomy, Clemson University, 216 Kinard Lab, Clemson, S.C. USA.
Physics and Astronomy, Clemson University, 302B Kinard Lab, Clemson, S.C. 29634-0978. USA.
Front Biosci (Landmark Ed). 2020 Jan 1;25(1):43-68. doi: 10.2741/4794.
Integrative and hybrid methods have the potential to bridge long-standing knowledge gaps in structural biology. These methods will have a prominent role in the future of the field as we make advances toward a complete, unified representation of biology that spans the molecular and cellular scales. The Department of Physics and Astronomy at Clemson University hosted The Future of Integrative Structural Biology workshop on April 29, 2017 and partially sponsored by partially sponsored by a program of the Oak Ridge Associated Universities (ORAU). The workshop brought experts from multiple structural biology disciplines together to discuss near-term steps toward the goal of a molecular atlas of the cell. The discussion focused on the types of structural data that should be represented, how this data should be represented, and how the time domain might be incorporated into such an atlas. The consensus was that an explorable, map-like Virtual Cell, containing both spatial and temporal data bridging the atomic and cellular length scales obtained by multiple experimental methods, represents the best path toward a complete atlas of the cell.
综合与混合方法有可能弥合结构生物学中长期存在的知识差距。随着我们朝着跨越分子和细胞尺度的生物学完整统一表示形式取得进展，这些方法将在该领域的未来发挥突出作用。克莱姆森大学物理与天文学系于 2017 年 4 月 29 日举办了“综合结构生物学的未来”研讨会，该研讨会部分由橡树岭大学联盟（ORAU）的一个项目部分赞助。该研讨会召集了来自多个结构生物学领域的专家，共同讨论实现细胞分子图谱目标的近期步骤。讨论的重点是应该表示哪些类型的结构数据、如何表示这些数据，以及如何将时间域纳入这样的图谱中。与会者一致认为，一个可探索的、类似地图的虚拟细胞，包含通过多种实验方法获得的跨越原子和细胞尺度的空间和时间数据，是实现细胞完整图谱的最佳途径。
