Burns G F, Boyd A W, Werkmeister J A, Triglia T, Andrews P
Immunology. 1985 May;55(1):1-6.
Human thymocytes differed from peripheral blood T cells, in that they did not proliferate in response to mouse monoclonal antibodies specific for the T3 antigen complex (UCHT1 and OKT3), even in the presence of T-cell growth factor (IL-2) or with monocytes plus IL-2. The failure to respond was not the result of inhibition by cortical thymocytes, since OKT6-negative cells also did not respond when tested under conditions of limiting dilution. Of more importance, these antibodies rendered human thymocytes unresponsive to the lectin phytohaemagglutinin when added before, during, or immediately after addition of the lectin, an effect which was much more profound than the decrease in mitogenesis caused with blood mononuclear cells. These results illustrate a clear difference between medullary thymocytes and peripheral T cells in their ability to respond to signals transduced through the T3 antigen complex.
人类胸腺细胞与外周血T细胞不同，在于它们即使在存在T细胞生长因子（白细胞介素-2）或单核细胞加白细胞介素-2的情况下，也不会对针对T3抗原复合物的小鼠单克隆抗体（UCHT1和OKT3）产生增殖反应。反应失败并非皮质胸腺细胞抑制的结果，因为在有限稀释条件下测试时，OKT6阴性细胞也没有反应。更重要的是，当在添加凝集素之前、期间或之后立即添加这些抗体时，它们会使人类胸腺细胞对凝集素植物血凝素无反应，这种效应比血液单核细胞引起的有丝分裂减少更为显著。这些结果表明，髓质胸腺细胞和外周T细胞在对通过T3抗原复合物转导的信号作出反应的能力上存在明显差异。
