Department of Cardiology, The Fourth Affiliated Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei, 050011, PR China.
Department of Basic Medicine, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, Hebei, 050017, PR China.
Eur J Pharmacol. 2019 Dec 1;864:172710. doi: 10.1016/j.ejphar.2019.172710. Epub 2019 Oct 2.
Danshensu is a pure molecule derived from Danshen, which is the root of the herb Salvia miltiorrhiza. It has a clearly defined chemical structure and demonstrates therapeutic effects in cardiovascular diseases (e.g., myocardial ischemia and reperfusion, atherosclerosis, hypertension), cerebral lesions and disorders (e.g., ischemia, cognitive decline, and anxiety), and other health problems (e.g., thrombosis, tumorigenesis, pancreatitis). The mechanisms behind these effects include antioxidation, anti-apoptosis, vasodilation, inflammation regulation, lipidemia control, etc., through the PI3K/Akt-ERK1/2/Nrf2/HO-1, Bcl-2/Bax, eNOS and other molecular signaling pathways. Both Danshen and Danshensu might be more effective than classical cardiovascular drugs, and their combination yields improved therapeutic efficiency. Here, we provide an overview of these drugs for a better understanding of Danshensu as a promising Chinese traditional medicine.
丹参素是从丹参中提取的一种纯分子，丹参是唇形科鼠尾草属植物的根。它具有明确的化学结构，对心血管疾病（如心肌缺血再灌注、动脉粥样硬化、高血压）、脑损伤和紊乱（如缺血、认知能力下降和焦虑）以及其他健康问题（如血栓形成、肿瘤发生、胰腺炎）具有明显的治疗作用。这些作用的机制包括抗氧化、抗细胞凋亡、血管舒张、炎症调节、血脂控制等，通过 PI3K/Akt-ERK1/2/Nrf2/HO-1、Bcl-2/Bax、eNOS 等分子信号通路。丹参和丹参素可能比经典的心血管药物更有效，它们的联合使用可以提高治疗效果。在这里，我们对这些药物进行了概述，以便更好地了解丹参素作为一种有前途的中药。
