Wertz P W, Miethke M C, Long S A, Strauss J S, Downing D T
J Invest Dermatol. 1985 May;84(5):410-2. doi: 10.1111/1523-1747.ep12265510.
Human epidermal surface lipids were collected by an ethanol wash and the ceramides were quantified by thin-layer chromatography-photodensitometry. Six ceramide fractions were isolated and the structural components of each were analyzed in detail. The most unusual of the epidermal ceramides contained a sphingosine base with amide-linked 30- and 32-carbon omega-hydroxyacids and an ester-linked nonhydroxyacid, 41% of which was linoleic acid. The proportion of linoleic acid in the analogous ceramide from comedones was 6%. This supports the hypothesis that a localized insufficiency of linoleic acid in the follicular epithelium is an etiologic factor in comedogenesis.
通过乙醇洗涤收集人表皮表面脂质，并用薄层色谱 - 光密度法对神经酰胺进行定量。分离出六个神经酰胺组分，并对每个组分的结构成分进行了详细分析。最不寻常的表皮神经酰胺含有一个鞘氨醇碱基，与酰胺连接的30碳和32碳ω - 羟基酸以及一个酯连接的非羟基酸，其中41%是亚油酸。来自粉刺的类似神经酰胺中亚油酸的比例为6%。这支持了以下假设：毛囊上皮中亚油酸的局部不足是粉刺形成的一个病因学因素。
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