Bowser P A, Nugteren D H, White R J, Houtsmuller U M, Prottey C
Biochim Biophys Acta. 1985 May 17;834(3):419-28. doi: 10.1016/0005-2760(85)90016-5.
Three specific linoleate-rich lipids have been identified in pig epidermis and are referred to as O-acylglucosyl ceramide, O-acyl ceramide, and O-acyl acid. The acid moiety is up to 70% linoleic acid and linked via the hydroxyl group of a omega-OH long-chain fatty acid, which itself is linked to sphingosine or glucosyl sphingosine. The identification of O-acyl ceramide confirmed the findings of another group, whereas the structural configuration of the O-acylglucosyl ceramide is different to previous reports. The identification of an O-acyl acid in epidermis is novel. Our evidence allows us to speculate that a hydroxylated derivative of the O-acyl ceramide may be intimately involved in the permeability barrier of skin, perhaps providing sufficient polarity to maintain a lamellar phase in the intercellular space of the lower stratum corneum region, and that it is specifically in this form that linoleic acid is involved in skin barrier function. Alternatively, or concurrently, this species may act as a signal for late keratinisation events.
在猪表皮中已鉴定出三种富含亚油酸的特定脂质，分别称为O - 酰基葡萄糖神经酰胺、O - 酰基神经酰胺和O - 酰基酸。酸部分高达70%为亚油酸，并通过ω - OH长链脂肪酸的羟基连接，该长链脂肪酸本身又与鞘氨醇或葡萄糖鞘氨醇相连。O - 酰基神经酰胺的鉴定证实了另一组的研究结果，而O - 酰基葡萄糖神经酰胺的结构构型与先前报道不同。表皮中O - 酰基酸的鉴定是新发现。我们的证据使我们推测，O - 酰基神经酰胺的羟基化衍生物可能与皮肤的渗透屏障密切相关，也许能提供足够的极性以维持角质层下部区域细胞间空间的片层相，并且正是以这种特定形式亚油酸参与皮肤屏障功能。或者，或者同时，这种物质可能作为晚期角质化事件的信号。
