Tzellos Thrasyvoulos, Zouboulis Christos C
Department of Dermatology, Nordland Hospital Trust, Bodø, Norway.
Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.
Dermatol Ther (Heidelb). 2020 Feb;10(1):63-71. doi: 10.1007/s13555-020-00354-2. Epub 2020 Jan 18.
Hidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. All this evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severity and effect of treatment, along with the use of clinically important patient reported outcomes, is essential. The potential of available treatments to negatively and positively affect these comorbidities should also be taken into account when designing treatment strategies. This review provides an outline of important HS comorbidities with emphasis on possible implications for daily clinical practice.
化脓性汗腺炎（HS）是一种慢性复发性皮肤炎症性疾病，与多种合并症相关，如生活质量下降、代谢综合征、性功能障碍、工作残疾、轴性脊柱关节炎、炎症性肠病、抑郁症和焦虑症。与银屑病一样，HS患者被发现有更高的心血管死亡风险和自杀风险。临床医生应了解这些合并症，以便进行适当的筛查。所有这些证据表明，对于这样一种慢性、多合并症的疾病，使用经过验证的结果来评估疾病严重程度和治疗效果，以及使用具有临床重要意义的患者报告结果，是至关重要的。在设计治疗策略时，还应考虑现有治疗方法对这些合并症产生负面和正面影响的可能性。本综述概述了HS的重要合并症，重点强调了对日常临床实践可能产生的影响。
