Durie B G, Grogan T M
Blood. 1985 Jul;66(1):229-32.
Detailed immunotyping was carried out on 21 direct myeloma bone marrow aspirates and eight human myeloma cell lines. Four previously untreated common acute lymphoblastic leukemia antigen (CALLA)-positive myeloma patients were identified and six of eight cell lines (75%) were also positive. CALLA positivity, as part of an immature B phenotype, was found to correlate with very aggressive clinical disease: median survival six months v 56 months for the CALLA-negative group.
对21份直接采集的骨髓瘤骨髓样本和8个人骨髓瘤细胞系进行了详细的免疫分型。确定了4例之前未经治疗的普通急性淋巴细胞白血病抗原（CALLA）阳性的骨髓瘤患者，并且8个细胞系中的6个（75%）也呈阳性。作为未成熟B表型的一部分，CALLA阳性与非常侵袭性的临床疾病相关：CALLA阴性组的中位生存期为6个月，而CALLA阳性组为56个月。
