基因编码的荧光钙指示剂和电压指示剂。
Genetically Encoded Fluorescent Calcium and Voltage Indicators.
作者信息
Mollinedo-Gajate Irene, Song Chenchen, Knöpfel Thomas
机构信息
Laboratory for Neuronal Circuit Dynamics, Imperial College London, London, UK.
出版信息
Handb Exp Pharmacol. 2019;260:209-229. doi: 10.1007/164_2019_299.
PMID:31595413
Abstract
Fluorescent probes that indicate biologically important quantities are widely used for many different types of biological experiments across life sciences. During recent years, limitations of small molecule-based indicators have been overcome by the development of genetically encoded indicators. Here we focus on fluorescent calcium and voltage indicators and point to their applications mainly in neurosciences.
摘要
用于指示生物学重要量值的荧光探针广泛应用于生命科学领域的许多不同类型的生物学实验。近年来，基于小分子的指示剂的局限性已通过基因编码指示剂的发展而得到克服。在这里，我们重点关注荧光钙指示剂和电压指示剂，并指出它们主要在神经科学中的应用。
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