Packer S, Lambrecht R M, Christman D R, Ansari A N, Wolf A P, Atkins H L
Am J Ophthalmol. 1977 Jan;83(1):80-94. doi: 10.1016/0002-9394(77)90195-7.
We studied radioactive metal compounds to determine their localization in malignant Greene melanoma in the eye of the Syrian golden hamsters. Scintigraphy of an ocular melanoma was achieved with several radioactive metals: radioactive indium(111In)-bleomycin, radioactive gallium (67Ga)-citrate, and radioactive lead (203Pb)-tris. The 111In-bleomycin had the highest tumor uptake (5.45% dose/g), but not the highest tumor-to-background ratios. The 67Ga-citrate had a maximum tumor uptake of 4.87% dose/g at 48 hours. The 111In-chloride had a melanoma uptake of 2.26% dose/g, while with 203Pbtris the uptake was 1.61% dose/g. These uptake ratios compare favorably with that of radioactive phosphorus (32P)-2.21% dose/g. Noninvasive localization of malignant melanoma in the eye was accomplished with metal isotopes. Detailed analysis of in vitro uptake date by tumor and background tissues revealed the optimum time for scanning and precluded unnecessary trials.
我们研究了放射性金属化合物，以确定它们在叙利亚金仓鼠眼部恶性格林黑色素瘤中的定位情况。通过几种放射性金属实现了眼部黑色素瘤的闪烁扫描：放射性铟（¹¹¹In）-博来霉素、放射性镓（⁶⁷Ga）-柠檬酸盐和放射性铅（²⁰³Pb）-三羟甲基氨基甲烷。¹¹¹In-博来霉素的肿瘤摄取率最高（5.45%剂量/克），但肿瘤与背景比值并非最高。⁶⁷Ga-柠檬酸盐在48小时时的最大肿瘤摄取率为4.87%剂量/克。¹¹¹In-氯化物的黑色素瘤摄取率为2.26%剂量/克，而²⁰³Pb-三羟甲基氨基甲烷的摄取率为1.61%剂量/克。这些摄取率与放射性磷（³²P）的摄取率2.21%剂量/克相比具有优势。利用金属同位素实现了眼部恶性黑色素瘤的非侵入性定位。对肿瘤和背景组织的体外摄取数据进行详细分析，确定了最佳扫描时间，避免了不必要的试验。
