生物钟控制的节律性转录：生物钟就足够了吗？它是如何工作的？
Clock-controlled rhythmic transcription: is the clock enough and how does it work?
作者信息
Beytebiere Joshua R, Greenwell Ben J, Sahasrabudhe Aishwarya, Menet Jerome S
机构信息
Department of Biology, Center for Biological Clock Research, Texas A&M University, TX, USA.
Program of Genetics, Texas A&M University, College Station, TX, USA.
出版信息
Transcription. 2019 Aug-Oct;10(4-5):212-221. doi: 10.1080/21541264.2019.1673636. Epub 2019 Oct 9.
Abstract
Circadian clocks regulate the rhythmic expression of thousands of genes underlying the daily oscillations of biological functions. Here, we discuss recent findings showing that circadian clock rhythmic transcriptional outputs rely on additional mechanisms than just clock gene DNA binding, which may ultimately contribute to the plasticity of circadian transcriptional programs.
摘要
昼夜节律时钟调节着数千个基因的节律性表达，这些基因是生物功能日常振荡的基础。在此，我们讨论最近的研究发现，这些发现表明昼夜节律时钟的节律性转录输出所依赖的机制不仅仅是时钟基因与DNA的结合，这最终可能有助于昼夜节律转录程序的可塑性。
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