红色诺卡氏菌细胞壁骨架和/或环磷酰胺对东海大鼠N-亚硝基-N-乙基脲诱导白血病发生的影响。
Effect of Nocardia rubra cell wall skeleton and/or cyclophosphamide on leukemogenesis induced by N-ethyl-N-nitrosourea in Donryu rats.
作者信息
Ogiu T, Furuta K, Matsuoka C, Maekawa A, Azuma I
出版信息
J Cancer Res Clin Oncol. 1985;109(3):173-7. doi: 10.1007/BF00390352.
The effect of Nocardia rubra cell wall skeleton (N-CWS) and/or cyclophosphamide (CP) on chemical carcinogenesis was examined in female Donryu rats exposed to N-ethyl-N-nitrosourea (ENU) in the drinking water for 6 weeks. Five administrations of N-CWS following ENU treatment caused a slight prolongation of the average survival of rats but did not reduce the incidence of leukemia. CP given on two occasions after ENU treatment caused a moderate prolongation of average survival period and a moderate reduction of the incidence of leukemia, but significant differences from ENU-treated control group values were not observed after statistical analysis. Combined treatment with N-CWS and CP after ENU treatment caused prolongation of the average survival period of rats and a statistically significant reduction in the incidence of leukemia. The present experiment indicates that combined treatment with N-CWS and CP effectively reduces induction of leukemia by ENU in rats, although other types of tumors were not affected.
在饮用含N-乙基-N-亚硝基脲（ENU）的水6周的雌性唐利大鼠中，研究了红色诺卡氏菌细胞壁骨架（N-CWS）和/或环磷酰胺（CP）对化学致癌作用的影响。ENU处理后给予5次N-CWS可使大鼠的平均生存期略有延长，但并未降低白血病的发生率。ENU处理后分两次给予CP可使平均生存期适度延长，白血病发生率适度降低，但经统计学分析后未观察到与ENU处理的对照组值有显著差异。ENU处理后联合使用N-CWS和CP可使大鼠的平均生存期延长，且白血病发生率有统计学意义的降低。本实验表明，尽管其他类型的肿瘤未受影响，但N-CWS和CP联合治疗可有效降低ENU诱导大鼠白血病的发生率。
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