Maekawa A, Ogiu T, Matsuoka C, Onodera H, Furuta K, Tanigawa H, Odashima S
J Cancer Res Clin Oncol. 1983;106(1):12-6. doi: 10.1007/BF00399891.
The carcinogenicity of N-carboxymethyl-N-nitrosourea (CMNU), a naturally occurring N-nitroso compound, was tested in female Donryu rats. Four groups of female Donryu rats were given 400, 200, 100, or 0 ppm of CMNU solution continuously as drinking water. The incidence of tumors was highest and the mean survival time shortest in the 400 ppm group. A dose-effect relationship was observed in the tumor incidence and the mean survival time and the incidences of tumors in all experimental groups were significantly different from those in the control group. In the 400 ppm group, tumors were detected most frequently in the small intestine, followed by the mammary gland. In contrast, most tumors were observed in the mammary gland in the other two experimental groups, although dose-dependent induction of tumors of the small intestine was also detected in these two groups. The organ specificity of CMNU is compared with that of other N-alkyl-N-nitrosourea derivatives.
对天然存在的N-亚硝基化合物N-羧甲基-N-亚硝基脲（CMNU）的致癌性在雌性Donryu大鼠中进行了测试。四组雌性Donryu大鼠连续饮用含400、200、100或0 ppm CMNU溶液的水。400 ppm组的肿瘤发生率最高，平均存活时间最短。在肿瘤发生率和平均存活时间方面观察到剂量效应关系，并且所有实验组的肿瘤发生率与对照组的显著不同。在400 ppm组中，肿瘤最常出现在小肠，其次是乳腺。相比之下，在其他两个实验组中，大多数肿瘤出现在乳腺，尽管在这两组中也检测到小肠肿瘤的剂量依赖性诱导。将CMNU的器官特异性与其他N-烷基-N-亚硝基脲衍生物的进行了比较。
