Skinner R B, Noah P W, Taylor R M, Zanolli M D, West S, Guin J D, Rosenberg E W
J Am Acad Dermatol. 1985 May;12(5 Pt 1):852-6. doi: 10.1016/s0190-9622(85)70107-7.
Thirty-seven patients with seborrheic dermatitis were treated topically with a 2% ketoconazole cream or its vehicle control in a double-blind study. The subjects were studied for numbers of Malassezia ovalis (Pityrosporum ovale) cells in their scalp scale; changes in numbers of yeast cells and morphology of M. ovalis were tabulated along with clinical assessment of improvement. The 2% ketoconazole cream, but not the placebo cream, reduced the numbers of viable yeast cells on the scalp. The clinical effect of 2% ketoconazole cream was good (75%-95% improvement) or better in eighteen of twenty subjects; the placebo cream produced good results in only three of seventeen subjects treated. Results of this study are consistent with the view that M. ovalis plays a central role in the pathogenesis of seborrheic dermatitis.
在一项双盲研究中，37名脂溢性皮炎患者接受了2%酮康唑乳膏或其赋形剂对照的局部治疗。研究了受试者头皮鳞屑中卵形马拉色菌（卵圆形糠秕孢子菌）细胞的数量；记录酵母细胞数量的变化和卵形马拉色菌的形态，并进行改善情况的临床评估。2%酮康唑乳膏而非安慰剂乳膏减少了头皮上活酵母细胞的数量。2%酮康唑乳膏对20名受试者中的18名临床效果良好（改善75%-95%）或更佳；安慰剂乳膏在17名接受治疗的受试者中仅3名取得了良好效果。本研究结果与卵形马拉色菌在脂溢性皮炎发病机制中起核心作用的观点一致。
