Kricker Anne, Weber Marianne F, Brenner Nicole, Banks Emily, Pawlita Michael, Sitas Freddy, Hodgkinson Verity S, Rahman Bayzid, van Kemenade Cathelijne H, Armstrong Bruce K, Waterboer Tim
Sydney School of Public Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Cancer Research Division, Cancer Council New South Wales, Sydney, New South Wales, Australia.
Cancer Epidemiol Biomarkers Prev. 2020 Jan;29(1):49-56. doi: 10.1158/1055-9965.EPI-19-0400. Epub 2019 Oct 9.
Human papillomavirus (HPV) infection is highly prevalent worldwide and may have a role, with sun exposure, in causing cutaneous squamous cell carcinoma. Little is known about the relationship of UV exposure and seroprevalence of cutaneous HPVs in the general population.
Using multiplex serology, we estimated the seroprevalence of 23 beta and 7 gamma HPVs and 7 other antigens (mu HPV1, HPV63, nu HPV41, alpha HPV16; polyomaviruses HPyV7 and MCV; p53) in a population-based sample of 1,161 Australian 45 and Up Study participants with valid data from blood specimens collected from 2010 to 2012. We calculated prevalence ratios (PR) for the association of each antigen with residential ambient solar UV and other UV-related variables.
Seropositivity for at least one beta or gamma HPV was high at 88% (beta HPVs 74%, gamma HPVs 70%), and less in women than men [e.g., PR beta-2 HPV38 = 0.70; 95% confidence interval (CI), 0.56-0.87; any gamma = 0.90; 95% CI, 0.84-0.97]. A high ambient UV level in the 10 years before study enrollment was associated with elevated seroprevalence for genus beta (PRtertile3vs1 any beta = 1.17; 95% CI, 1.07-1.28), and beta-1 to beta-3 species, but not for gamma HPVs. Other UV-related measures had less or no evidence of an association.
Seroprevalence of cutaneous beta HPVs is higher with higher ambient UV exposure in the past 10 years.
The observed association between ambient UV in the past 10 years and cutaneous HPVs supports further study of the possible joint role of solar UV and HPV in causing skin cancer.
人乳头瘤病毒（HPV）感染在全球高度流行，并且可能与阳光照射共同作用导致皮肤鳞状细胞癌。对于普通人群中紫外线暴露与皮肤HPV血清阳性率之间的关系，人们了解甚少。
我们采用多重血清学方法，在1161名澳大利亚45岁及以上研究参与者的人群样本中，估计了23种β型和7种γ型HPV以及7种其他抗原（μHPV1、HPV63、νHPV41、αHPV16；多瘤病毒HPyV7和MCV；p53）的血清阳性率，这些参与者拥有2010年至2012年采集的血液标本的有效数据。我们计算了每种抗原与居住环境太阳紫外线及其他紫外线相关变量之间关联的患病率比值（PR）。
至少一种β型或γ型HPV的血清阳性率很高，为88%（β型HPV为74%，γ型HPV为70%），女性低于男性[例如，PRβ-2 HPV38 = 0.70；95%置信区间（CI），0.56 - 0.87；任何γ型 = 0.90；95% CI，0.84 - 0.97]。研究入组前10年的高环境紫外线水平与β属（PRtertile3vs1任何β型 = 1.17；95% CI，1.07 - 1.28）以及β-1至β-3种的血清阳性率升高相关，但与γ型HPV无关。其他紫外线相关指标的关联证据较少或没有关联证据。
过去10年环境紫外线暴露越高，皮肤β型HPV的血清阳性率越高。
过去10年环境紫外线与皮肤HPV之间观察到的关联支持进一步研究太阳紫外线和HPV在导致皮肤癌方面可能的联合作用。
